Ketoprofen and Ultram drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Ketoprofen (ketoprofen) and Ultram (tramadol hydrochloride). Common drug interactions include drug ineffective among females and chronic kidney disease among males.

The phase IV clinical study analyzes what interactions people have when they take Ketoprofen and Ultram. It is created by eHealthMe based on reports of 58 people who take the same drugs from the FDA, and is updated regularly.

What is Ketoprofen?

Ketoprofen has active ingredients of ketoprofen. It is often used in pain. eHealthMe is studying from 15,048 Ketoprofen users. Check the latest studies of Ketoprofen.

What is Ultram?

Ultram has active ingredients of tramadol hydrochloride. It is often used in pain. eHealthMe is studying from 28,425 Ultram users. Check the latest studies of Ultram.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 02, 2026

58 people who take Ketoprofen and Ultram together, and have interactions are studied.

Ketoprofen and Ultram drug interactions.

What are the common drug interactions of Ketoprofen and Ultram, by gender? *:

female:

Drug ineffective
Fall
Osteoarthritis (a joint disease caused by cartilage loss in a joint)
Palpitations (feelings or sensations that your heart is pounding or racing)
Panic attack
Abdominal pain
Acanthoma (a skin cancer)
Agitation (state of anxiety or nervous excitement)
Anorexia (eating disorder characterized by immoderate food restriction and irrational fear of gaining weight)
Anxiety

male:

Chronic kidney disease
Fall
Compression fracture (fracture due to pressure caused by injury)
Dizziness
Mobility decreased (ability to move is reduced)
Musculoskeletal pain (pain affects the bones, muscles, ligaments, tendons, and nerves)
Neck pain
Rotator cuff syndrome (a spectrum of conditions affecting the rotator cuff tendons of the shoulder)
Somnambulism (sleep walking)
Abnormal faeces (abnormal stool)

What are the common drug interactions of Ketoprofen and Ultram, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Nausea (feeling of having an urge to vomit)
Abdominal pain
Cholecystitis acute (rapid infection of gallbladder)
Cholecystitis chronic (long lasting infection of gallbladder)
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Gallbladder injury
Hypertension (high blood pressure)
Intentional self-injury
Liver injury
Muscle injury

30-39:

Arthralgia (joint pain)
Blood alkaline phosphatase increased
Chest pain
Joint swelling
Knee deformity (functional disability of knee)
Metatarsalgia (injury described as pain in the forefoot that is associated with increased stress)
Mobility decreased (ability to move is reduced)
Troponin increased
Weight bearing difficulty (difficulty due to weight of thigh fat deposition)
Diabetic neuropathy (neuropathic disorders that are associated with diabetes mellitus)

40-49:

Acanthoma (a skin cancer)
Atrioventricular block complete (heart block complete)
Coronary artery disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)
Hyperkeratosis (thickening of the outer layer of the skin)
Interstitial lung disease
Lobar pneumonia (a form of pneumonia that affects a large and continuous area of the lobe of a lung)
Mitral valve incompetence (inefficient heart valve)
Mitral valve stenosis (narrowing of mitral valve)
Pericardial effusion (fluid around the heart)
Pleurisy (inflammation of the pleurae, which causes pain when breathing)

50-59:

Fall
Pain in extremity
Depression
Alanine aminotransferase increased
Arthralgia (joint pain)
Aspartate aminotransferase increased
Constipation
Drug abuser
Drug ineffective
Neck pain

60+:

Chronic kidney disease
Renal failure (kidney dysfunction)
Confusion
Convulsions (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled of muscles contract and relax rapidly and repeatedly)
Creatinine renal clearance decreased
Disorientation (disability in which the senses of time, direction, and recognition of people and places)
Fall
Gastric ulcer (stomach ulcer)
Haematuria (presence of blood in urine)
Haemoglobin decreased

What are the existing conditions these people have? *

Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 7 people, 12.07%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 6 people, 10.34%
Type 2 Diabetes: 5 people, 8.62%
Depression: 5 people, 8.62%
Back Pain: 5 people, 8.62%
Multiple Allergies (allergy to multiple agents): 5 people, 8.62%
Cardiac Disorder: 5 people, 8.62%
Inflammation: 5 people, 8.62%
Infection: 5 people, 8.62%
Indigestion: 5 people, 8.62%

* Approximation only. Some reports may have incomplete information.

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