Naproxen and Optimark drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Naproxen (naproxen) and Optimark (gadoversetamide). Common drug interactions include ocular icterus among females and mobility decreased among males.

The phase IV clinical study analyzes what interactions people have when they take Naproxen and Optimark. It is created by eHealthMe based on reports of 15 people who take the same drugs from the FDA, and is updated regularly.

What is Naproxen?

Naproxen has active ingredients of naproxen. It is often used in pain. eHealthMe is studying from 72,034 Naproxen users. Check the latest studies of Naproxen.

What is Optimark?

Optimark has active ingredients of gadoversetamide. eHealthMe is studying from 3,055 Optimark users. Check the latest studies of Optimark.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 02, 2026

15 people who take Naproxen and Optimark together, and have interactions are studied.

Naproxen and Optimark drug interactions.

What are the common drug interactions of Naproxen and Optimark, by gender? *:

female:

Ocular icterus (presence of jaundice seen in the sclera of the eye)
Pruritus (severe itching of the skin)
Purpura (purplish discoloration of the skin)
Rash
Rash macular (small, flat red spots)
Rash papular (redness with papule)
Scar
Skin burning sensation
Skin discolouration (change of skin colour)
Skin fibrosis (fibrous tissue formation on skin)

male:

Mobility decreased (ability to move is reduced)
Nephrogenic systemic fibrosis (involves fibrosis of skin, joints, eyes due to kidney disease)
Hypoaesthesia (reduced sense of touch or sensation)
Pain in extremity
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Peripheral coldness
Skin exfoliation (removal of the oldest dead skin cells)
Skin fissures (a crack in the skin)
Skin induration (an abnormally hard spot or area on the skin)
Skin lesion

What are the common drug interactions of Naproxen and Optimark, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Osteoporosis (bones weak and more likely to break)
Overdose
Pneumonia aspiration (bronchopneumonia that develops due to the entrance of foreign materials into the bronchial tree)
Renal failure chronic (long lasting kidney dysfunction)
Shock (a life-threatening condition with symptoms like low blood pressure, weakness, shallow breathing, cold, clammy skin)
Tachycardia (a heart rate that exceeds the range of 100 beats/min)
Thrombocytopenia (decrease of platelets in blood)
Urinary tract infection
Vision blurred
Nephrogenic systemic fibrosis (involves fibrosis of skin, joints, eyes due to kidney disease)

50-59:

n/a

60+:

Mobility decreased (ability to move is reduced)
Nephrogenic systemic fibrosis (involves fibrosis of skin, joints, eyes due to kidney disease)
Muscular weakness (muscle weakness)
Pain in extremity
Pruritus (severe itching of the skin)
Scar
Skin burning sensation
Skin induration (an abnormally hard spot or area on the skin)
Pain of skin
Anhedonia (inability to experience pleasure from activities usually found enjoyable)

What are the existing conditions these people have? *

Nuclear Magnetic Resonance Imaging Brain: 12 people, 80.00%
Hyperphosphataemia (electrolyte disturbance in which there is an abnormally elevated level of phosphate in the blood): 6 people, 40.00%
Peripheral Arterial Occlusive Disease (reproducible ischemic muscle pain): 3 people, 20.00%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 3 people, 20.00%
High Blood Pressure: 3 people, 20.00%
High Blood Cholesterol: 3 people, 20.00%
Arthritis (form of joint disorder that involves inflammation of one or more joints): 3 people, 20.00%
Anaemia (lack of blood): 3 people, 20.00%
Renal Mass (mass in kidney): 2 people, 13.33%
Renal Abscess (pus in kidney): 2 people, 13.33%

* Approximation only. Some reports may have incomplete information.

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