Centrum and Pramine drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Centrum (ascorbic acid; biotin; cyanocobalamin; dexpanthenol; ergocalciferol; folic acid; niacinamide; pyridoxine hydrochloride; riboflavin phosphate sodium; thiamine hydrochloride; vitamin a; vitamin e) and Pramine (imipramine hydrochloride). Common drug interactions include asthenia among females and abasia among males.

The phase IV clinical study analyzes what interactions people have when they take Centrum and Pramine. It is created by eHealthMe based on reports of 43 people who take the same drugs from the FDA, and is updated regularly.

What is Centrum?

Centrum has active ingredients of ascorbic acid; biotin; cyanocobalamin; dexpanthenol; ergocalciferol; folic acid; niacinamide; pyridoxine hydrochloride; riboflavin phosphate sodium; thiamine hydrochloride; vitamin a; vitamin e. It is often used in vitamin supplementation. eHealthMe is studying from 34,686 Centrum users. Check the latest studies of Centrum.

What is Pramine?

Pramine has active ingredients of imipramine hydrochloride. eHealthMe is studying from 7,461 Pramine users. Check the latest studies of Pramine.

On Jul, 11, 2026

43 people who take Centrum and Pramine together, and have interactions are studied.

What are the common drug interactions of Centrum and Pramine, by gender? *:

female:

Asthenia (weakness)
Hyperlipidaemia (presence of excess lipids in the blood)
Blood pressure increased
Dizziness
Vision blurred
Ataxia (loss of full control of bodily movements)
Drug ineffective
Dyspnoea (difficult or laboured respiration)
Hypertension (high blood pressure)
Injection site erythema (redness at injection site)

male:

Abasia (inability to walk)
Cardiac failure congestive
Constipation
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Hypokalaemia (low potassium)
Hyponatraemia (abnormally low level of sodium in the blood; associated with dehydration)
Multiple injuries
Muscle twitching
Sciatica (a set of symptoms including pain caused by general compression or irritation of one of five spinal nerve roots of each sciatic nerve)

What are the common drug interactions of Centrum and Pramine, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Leukopenia (less number of white blood cells in blood)

30-39:

Blood pressure increased
Cardiomegaly (increased size of heart than normal)
Chest pain
Dizziness
Dyspnoea (difficult or laboured respiration)
Injection site erythema (redness at injection site)
Injection site pain
Oesophageal reflux (moving the food downwards)
Pulmonary hypertension primary (increase in blood pressure in the lung artery with no cause)
Valvular heart disease (diseases of the heart valves)

40-49:

Abnormal behaviour
Catatonia (unresponsive to external stimuli)
Fall
Flat affect (absence of emotional response to a situation)
Grand mal convulsion (a type of generalized seizure that affects the entire brain)
Incoherent (talking in a confused and unclear way)
Judgement impaired
Aphasia (damage to the parts of the brain that control language)
Confusion
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)

50-59:

Rheumatoid arthritis (a chronic progressive disease causing inflammation in the joints)
Sleep apnoea syndrome (a sleep-related disorder in which the effort to breathe is diminished or absent)
Supraventricular tachycardia (rapid heart rhythm originating at or above the atrioventricular node)
Temporomandibular joint syndrome (pain at the temporomandibular joint due to various causes of increased muscle tension and spasm. it is believed that syndrome is a physical manifestation of psychological stress)
Type 2 diabetes mellitus
Upper respiratory tract infection
Vaginal haemorrhage (vaginal bleeding)
Vomiting
Weight increased
Asthma

60+:

Asthenia (weakness)
Ataxia (loss of full control of bodily movements)
Pathological fracture (broken bone caused by disease)
Radius fracture
Spinal fusion surgery
Urine calcium decreased
Vitamin d decreased
Abasia (inability to walk)
Alopecia (absence of hair from areas of the body)
Blindness transient (sudden loss of vision)

What are the existing conditions these people have? *

Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 5 people, 11.63%
Drowsiness: 4 people, 9.30%
Pain: 3 people, 6.98%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 3 people, 6.98%
Depression: 3 people, 6.98%

* Approximation only. Some reports may have incomplete information.

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