Centrum and Vyvanse drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Centrum (ascorbic acid; biotin; cyanocobalamin; dexpanthenol; ergocalciferol; folic acid; niacinamide; pyridoxine hydrochloride; riboflavin phosphate sodium; thiamine hydrochloride; vitamin a; vitamin e) and Vyvanse (lisdexamfetamine dimesylate). Common drug interactions include insomnia among females and alcohol abuse among males.

The phase IV clinical study analyzes what interactions people have when they take Centrum and Vyvanse. It is created by eHealthMe based on reports of 33 people who take the same drugs from the FDA, and is updated regularly.

What is Centrum?

Centrum has active ingredients of ascorbic acid; biotin; cyanocobalamin; dexpanthenol; ergocalciferol; folic acid; niacinamide; pyridoxine hydrochloride; riboflavin phosphate sodium; thiamine hydrochloride; vitamin a; vitamin e. It is often used in vitamin supplementation. eHealthMe is studying from 34,686 Centrum users. Check the latest studies of Centrum.

What is Vyvanse?

Vyvanse has active ingredients of lisdexamfetamine dimesylate. It is often used in attention deficit hyperactivity disorder. eHealthMe is studying from 35,868 Vyvanse users. Check the latest studies of Vyvanse.

On Jul, 06, 2026

33 people who take Centrum and Vyvanse together, and have interactions are studied.

What are the common drug interactions of Centrum and Vyvanse, by gender? *:

female:

Insomnia (sleeplessness)
Abdominal pain upper
Cholecystitis acute (rapid infection of gallbladder)
Drug ineffective
Hernia (hernia happens when part of an internal organ or tissue bulges through a weak area of muscle)
Myalgia (muscle pain)
Anxiety
Feeling cold
Rash
Respiratory tract infection

male:

Alcohol abuse
Anxiety
Hypersensitivity
Infection
Somnolence (a state of near-sleep, a strong desire for sleep)
Tooth extraction
Tooth infection
Toothache (tooth pain)
Angular cheilitis (inflammation of one, or more commonly both, of the corners of the mouth)
Accident

What are the common drug interactions of Centrum and Vyvanse, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Abnormal dreams
Aggression
Anxiety
Disturbance in attention
Dizziness
Headache (pain in head)
Hypoaesthesia (reduced sense of touch or sensation)
Increased appetite
Irritability
Memory impairment

20-29:

Angular cheilitis (inflammation of one, or more commonly both, of the corners of the mouth)
Feeling cold
Feeling hot
Loss of consciousness
Lymphadenopathy (disease or enlargement of lymph nodes)
Oropharyngeal pain

30-39:

Blister (small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure)
Carpal tunnel syndrome (nerve compression at wrist results numbness weakness, pain , swelling)
Cellulitis (infection under the skin)
Enuresis (repeated inability to control urination)
Feeling cold
Insomnia (sleeplessness)
Joint swelling
Local swelling (swelling at the site of some application of substance or injury)
Myalgia (muscle pain)
Oedema peripheral (superficial swelling)

40-49:

Abdominal pain upper
Cholecystitis acute (rapid infection of gallbladder)
Hernia (hernia happens when part of an internal organ or tissue bulges through a weak area of muscle)
Alcohol abuse
Anxiety
Chest discomfort
Disability
Muscle tightness
Obsessive-compulsive disorder (an anxiety disorder characterized by intrusive thoughts that produce uneasiness, apprehension, fear, or worry;)
Weight increased

50-59:

n/a

60+:

Drug ineffective
Balance disorder
Tooth infection
Toothache (tooth pain)
Fall
Insomnia (sleeplessness)
Nausea (feeling of having an urge to vomit)
Bruxism (habitual grinding of the teeth, typically during sleep)
Dementia (madness)
Dental caries

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 12 people, 36.36%
Asthma: 5 people, 15.15%
Depression: 4 people, 12.12%
Affective Disorder (mental disorder): 3 people, 9.09%
High Blood Cholesterol: 3 people, 9.09%
Arthritis (form of joint disorder that involves inflammation of one or more joints): 2 people, 6.06%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 2 people, 6.06%
Diabetic Neuropathy (neuropathic disorders that are associated with diabetes mellitus): 2 people, 6.06%
Dizziness: 2 people, 6.06%
Drowsiness: 2 people, 6.06%

* Approximation only. Some reports may have incomplete information.

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