Chlorothiazide and Clonazepam drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Chlorothiazide (chlorothiazide) and Clonazepam (clonazepam). Common drug interactions include discomfort among females and respiratory failure among males.

The phase IV clinical study analyzes what interactions people have when they take Chlorothiazide and Clonazepam. It is created by eHealthMe based on reports of 31 people who take the same drugs from the FDA, and is updated regularly.

What is Chlorothiazide?

Chlorothiazide has active ingredients of chlorothiazide. eHealthMe is studying from 1,220 Chlorothiazide users. Check the latest studies of Chlorothiazide.

What is Clonazepam?

Clonazepam has active ingredients of clonazepam. It is often used in stress and anxiety. eHealthMe is studying from 146,271 Clonazepam users. Check the latest studies of Clonazepam.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 20, 2026

31 people who take Chlorothiazide and Clonazepam together, and have interactions are studied.

Chlorothiazide and Clonazepam drug interactions.

What are the common drug interactions of Chlorothiazide and Clonazepam, by gender? *:

female:

Discomfort
Dyspnoea (difficult or laboured respiration)
Emphysema (chronic respiratory disease - over inflation of the air sacs (alveoli) in the lungs)
Headache (pain in head)
Herpes zoster
Hospitalisation
Injection site discolouration
Injection site erythema (redness at injection site)
Kidney infection
Macule (a discoloured spot on the skin)

male:

Respiratory failure (inadequate gas exchange by the respiratory system)
Hypotension (abnormally low blood pressure)
Malnutrition (a condition that results from eating a diet in which certain nutrients are lacking)
Nausea (feeling of having an urge to vomit)
Pneumonia
Renal failure acute (rapid kidney dysfunction)
Renal failure chronic (long lasting kidney dysfunction)
Sepsis (a severe blood infection that can lead to organ failure and death)
Shock (a life-threatening condition with symptoms like low blood pressure, weakness, shallow breathing, cold, clammy skin)
Subdural haematoma (blood collects between the skull and the surface of the brain)

What are the common drug interactions of Chlorothiazide and Clonazepam, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Pulmonary arterial hypertension (high blood pressure in the arteries of lungs)
Pyrexia (fever)
Right ventricular failure (right half of the heart fails to work)
Septic shock (shock due to blood infection)
Staphylococcal infection (an infection with staphylococcus bacteria)
Cytokine release syndrome (immediate complication occurring with the use of anti-t cell antibody infusions)
Hypotension (abnormally low blood pressure)
Hypoxia (low oxygen in tissues)
Respiratory failure (inadequate gas exchange by the respiratory system)
Blood culture positive

20-29:

n/a

30-39:

Breast pain
Cough
Device dislocation
Malaise (a feeling of general discomfort or uneasiness)
Menorrhagia (an abnormally heavy bleeding and prolonged menstrual period at regular intervals)
Nervousness
Pain in extremity
Pneumonia
Abdominal distension
Cardiac failure

40-49:

n/a

50-59:

Back pain
Crying
Decreased appetite
Diplegia (paralysis of corresponding parts on both sides of the body)
Injection site haematoma (localized swelling filled with blood at injection site)
Injection site pain
Lower extremity mass (mass in lower legs)
Mobility decreased (ability to move is reduced)
Multiple sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)
Muscular weakness (muscle weakness)

60+:

Pneumonia
Anaemia (lack of blood)
Nausea (feeling of having an urge to vomit)
Renal failure acute (rapid kidney dysfunction)
Renal failure chronic (long lasting kidney dysfunction)
Respiratory failure (inadequate gas exchange by the respiratory system)
Sepsis (a severe blood infection that can lead to organ failure and death)
Shock (a life-threatening condition with symptoms like low blood pressure, weakness, shallow breathing, cold, clammy skin)
Subdural haematoma (blood collects between the skull and the surface of the brain)
Thrombocytopenia (decrease of platelets in blood)

What are the existing conditions these people have? *

High Blood Pressure: 6 people, 19.35%
High Blood Cholesterol: 4 people, 12.90%
Sleep Disorder: 3 people, 9.68%
Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 3 people, 9.68%
Depression: 3 people, 9.68%
Birth Control: 3 people, 9.68%
Secondary Progressive Multiple Sclerosis (a stage of ms which comes after relapsing remitting ms in many cases): 2 people, 6.45%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 2 people, 6.45%
Pharyngitis (inflammation of the pharynx, causing a sore throat): 2 people, 6.45%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 2 people, 6.45%

* Approximation only. Some reports may have incomplete information.

Do you take Chlorothiazide and Clonazepam?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously