Chlorothiazide and Clonidine drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Chlorothiazide (chlorothiazide) and Clonidine (clonidine). Common drug interactions include intraocular pressure increased among females and atrioventricular block among males.

The phase IV clinical study analyzes what interactions people have when they take Chlorothiazide and Clonidine. It is created by eHealthMe based on reports of 77 people who take the same drugs from the FDA, and is updated regularly.

What is Chlorothiazide?

Chlorothiazide has active ingredients of chlorothiazide. eHealthMe is studying from 1,220 Chlorothiazide users. Check the latest studies of Chlorothiazide.

What is Clonidine?

Clonidine has active ingredients of clonidine. It is often used in high blood pressure. eHealthMe is studying from 65,644 Clonidine users. Check the latest studies of Clonidine.

On Jul, 14, 2026

77 people who take Chlorothiazide and Clonidine together, and have interactions are studied.

Chlorothiazide and Clonidine drug interactions.

What are the common drug interactions of Chlorothiazide and Clonidine, by gender? *:

female:

Intraocular pressure increased
Malignant neoplasm progression (cancer tumour came back)
Mouth haemorrhage (bleeding from mouth)
Muscular weakness (muscle weakness)
Nasal flaring (nostrils widen while a person is breathing)
Nausea (feeling of having an urge to vomit)
Neck mass (mass in neck)
Neurotoxicity (when the exposure to natural or artificial toxic substances, which are called neurotoxins, alters the normal activity of the nervous system)
Nodule (a growth of abnormal tissue)
Oral pain

male:

Atrioventricular block (heart block)
Loss of consciousness
Carpal tunnel syndrome (nerve compression at wrist results numbness weakness, pain , swelling)
Fatigue (feeling of tiredness)
Lipoma (a growth of fatty tissue that slowly develops just under your skin)
Pneumonia
Respiratory failure (inadequate gas exchange by the respiratory system)
Weight decreased
Weight gain poor
Rectal haemorrhage (bleeding from anus)

What are the common drug interactions of Chlorothiazide and Clonidine, by age (0-1 to 60+)? *:

0-1:

Drug ineffective
Hospitalisation
Respiratory distress (difficulty in breathing)
Agitation (state of anxiety or nervous excitement)
Diarrhoea
Drug-induced liver injury (diseases of the liver that are caused by physician-prescribed medications)
Dyspnoea (difficult or laboured respiration)
Failure to thrive (inadequate weight gain and physical growth in children)
Hepatotoxicity (chemical-driven liver damage)
Hypochloraemia (electrolyte disturbance in which there is an abnormally low level of the chloride ion in the blood)

2-9:

Pneumonia fungal
Device dislocation
Pneumatosis intestinalis (air or gas in an intestine)
Pneumonia aspiration (bronchopneumonia that develops due to the entrance of foreign materials into the bronchial tree)
Respiratory failure (inadequate gas exchange by the respiratory system)
Septic shock (shock due to blood infection)
Umbilical hernia (an outward bulging (protrusion) of the abdominal lining or part of the abdominal organ(s) through the area around the belly button)
Urinary tract infection
Weight gain poor
Atrioventricular block (heart block)

10-19:

Pain
Cardiac arrest
Chest pain
Chloroma (green-coloured tumour)
Cough
Cytokine release syndrome (immediate complication occurring with the use of anti-t cell antibody infusions)
Depressed level of consciousness
Drug ineffective
Dyspnoea (difficult or laboured respiration)
Exophthalmos (bulging or protruding eyeball)

20-29:

Hernia (hernia happens when part of an internal organ or tissue bulges through a weak area of muscle)
Loss of consciousness
Pneumothorax (the presence of air or gas in the cavity between the lungs and the chest wall, causing collapse of the lung)
Tracheostomy infection (infection of trachea surgical opening)
Pyrexia (fever)
Respiratory disorder (respiratory disease)
Pneumonia

30-39:

n/a

40-49:

Bipolar disorder (mood disorder)
Cardiac disorder
Chest pain
Dizziness
Drug intolerance (drug sensitivity)
Fall
Glomerulonephritis proliferative (a disorder of the glomeruli (glomerulonephritis), or small blood vessels in the kidneys)
Hallucination, auditory (perceiving sounds without auditory stimulus)
Polydipsia (excessive thirst)
Renal failure (kidney dysfunction)

50-59:

Abasia (inability to walk)
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Calcification of muscle (calcium accumulation in muscle)
Dysphonia (speech disorder attributable to a disorder of phonation)
Extremity contracture (permanent shortening of a muscle or joint of arms and legs)
Impaired self-care
International normalised ratio increased
Joint contracture (a permanent shortening of a muscle or joint)
Joint range of motion decreased (disease of joint movement)
Joint stiffness

60+:

Chronic kidney disease
Renal failure (kidney dysfunction)
Blood creatine phosphokinase increased
Blood triglycerides increased
Chills (felling of cold)
Constipation
Coronary artery disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)
Drug ineffective
Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation)
Dry skin

What are the existing conditions these people have? *

Pain: 13 people, 16.88%
Acute Lymphocytic Leukemia (All) (cancer of the white blood cells characterized by excess lymphoblasts): 9 people, 11.69%
Fever: 8 people, 10.39%
The Flu (the flu is caused by an influenza virus): 8 people, 10.39%
Infection: 7 people, 9.09%
Respiratory Distress (difficulty in breathing): 7 people, 9.09%
Itching: 6 people, 7.79%
Flatulence (flatus expelled through the anus): 6 people, 7.79%
Anaphylaxis (serious allergic reaction that is rapid in onset and may cause death): 6 people, 7.79%
Gastrointestinal Disorder (functional problems of gastrointestinal tract): 6 people, 7.79%

* Approximation only. Some reports may have incomplete information.

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