Chlorothiazide and Zantac drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Chlorothiazide (chlorothiazide) and Zantac (ranitidine hydrochloride). Common drug interactions include arrhythmia among females and renal failure acute among males.

The phase IV clinical study analyzes what interactions people have when they take Chlorothiazide and Zantac. It is created by eHealthMe based on reports of 16 people who take the same drugs from the FDA, and is updated regularly.

What is Chlorothiazide?

Chlorothiazide has active ingredients of chlorothiazide. eHealthMe is studying from 1,220 Chlorothiazide users. Check the latest studies of Chlorothiazide.

What is Zantac?

Zantac has active ingredients of ranitidine hydrochloride. It is often used in gastroesophageal reflux disease. eHealthMe is studying from 434,161 Zantac users. Check the latest studies of Zantac.

On Feb, 02, 2026

16 people who take Chlorothiazide and Zantac together, and have interactions are studied.

Chlorothiazide and Zantac drug interactions.

What are the common drug interactions of Chlorothiazide and Zantac, by gender? *:

female:

Arrhythmia (irregular heartbeat)
Atrioventricular block (heart block)
Bipolar disorder (mood disorder)
Blood pressure decreased
Cardiac disorder
Cardio-respiratory arrest (sudden dysfunction of heart and lungs)
Chest pain
Chronic kidney disease
Dizziness
Drug intolerance (drug sensitivity)

male:

Renal failure acute (rapid kidney dysfunction)
Death
Acute generalised exanthematous pustulosis (acute febrile drug eruption)
Alanine aminotransferase increased
Anaemia (lack of blood)
Aspartate aminotransferase increased
Atrial thrombosis (blood clot that develops in an artery)
Blood calcium decreased
Blood parathyroid hormone increased
Blood potassium decreased

What are the common drug interactions of Chlorothiazide and Zantac, by age (0-1 to 60+)? *:

0-1:

Death
Injury
Pain
Renal failure (kidney dysfunction)
Renal failure acute (rapid kidney dysfunction)
Renal injury (kidney injury)
Alanine aminotransferase increased
Aspartate aminotransferase increased
Atrial thrombosis (blood clot that develops in an artery)
Cardiac failure congestive

2-9:

Death
Infusion site erythema (reddening of the skin at infusion site)
Infusion site induration
Infusion site infection
Localised infection (infection at the single location)

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Bipolar disorder (mood disorder)
Cardiac disorder
Chest pain
Dizziness
Drug intolerance (drug sensitivity)
Fall
Hallucination, auditory (perceiving sounds without auditory stimulus)
Injection site pain
Polydipsia (excessive thirst)
Type 2 diabetes mellitus

50-59:

Cardio-respiratory arrest (sudden dysfunction of heart and lungs)
Dyspnoea (difficult or laboured respiration)
Erythema multiforme (a type of hypersensitivity reaction)
Hyponatraemia (abnormally low level of sodium in the blood; associated with dehydration)
Hypotension (abnormally low blood pressure)
Hypovolaemia (a decreased volume of circulating blood in the body)
Ischaemic cardiomyopathy (weakness in the muscle of the heart due to inadequate oxygen delivery to the myocardium with coronary artery disease)
Metabolic acidosis (body produces too much acid, or when the kidneys are not removing enough acid from the body)
Nephrogenic anaemia (anaemia due to kidney disease)
Renal failure acute (rapid kidney dysfunction)

60+:

Blood pressure decreased
Ejection fraction decreased (systolic heart failure)

What are the existing conditions these people have? *

Depression: 3 people, 18.75%
Blood Pressure Abnormal: 2 people, 12.50%
Pain: 2 people, 12.50%
Graft Versus Host Disease (the donated bone marrow or stem cells view the recipient's body as foreign, and the donated cells/bone marrow attack the body): 2 people, 12.50%
Indigestion: 2 people, 12.50%
Schizophrenia (a mental disorder characterized by a breakdown of thought processes): 1 person, 6.25%
High Blood Cholesterol: 1 person, 6.25%
Bipolar Disorder (mood disorder): 1 person, 6.25%
Cardiac Disorder: 1 person, 6.25%
Cardiac Failure: 1 person, 6.25%

* Approximation only. Some reports may have incomplete information.

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