Chlorothiazide and Zofran drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Chlorothiazide (chlorothiazide) and Zofran (ondansetron hydrochloride). Common drug interactions include diarrhoea among females and anaemia among males.

The phase IV clinical study analyzes what interactions people have when they take Chlorothiazide and Zofran. It is created by eHealthMe based on reports of 17 people who take the same drugs from the FDA, and is updated regularly.

What is Chlorothiazide?

Chlorothiazide has active ingredients of chlorothiazide. eHealthMe is studying from 1,220 Chlorothiazide users. Check the latest studies of Chlorothiazide.

What is Zofran?

Zofran has active ingredients of ondansetron hydrochloride. It is often used in nausea. eHealthMe is studying from 94,987 Zofran users. Check the latest studies of Zofran.

On Jul, 13, 2026

17 people who take Chlorothiazide and Zofran together, and have interactions are studied.

Chlorothiazide and Zofran drug interactions.

What are the common drug interactions of Chlorothiazide and Zofran, by gender? *:

female:

Diarrhoea
Dizziness
Epistaxis (bleed from the nose)
Fluid retention (an abnormal accumulation of fluid in the blood)
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Haemoptysis (blood-stained sputum from the bronchi, larynx, trachea, or lungs)
Hyperkalaemia (damage to or disease of the kidney)
Magnesium deficiency (lack of magnesium)
Nasopharyngitis (inflammation of the nasopharynx)
Oedema (fluid collection in tissue)

male:

Anaemia (lack of blood)
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Renal failure acute (rapid kidney dysfunction)
Renal failure chronic (long lasting kidney dysfunction)
Respiratory failure (inadequate gas exchange by the respiratory system)
Sepsis (a severe blood infection that can lead to organ failure and death)
Shock (a life-threatening condition with symptoms like low blood pressure, weakness, shallow breathing, cold, clammy skin)
Subdural haematoma (blood collects between the skull and the surface of the brain)
Thrombocytopenia (decrease of platelets in blood)
Dyspnoea (difficult or laboured respiration)

What are the common drug interactions of Chlorothiazide and Zofran, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Blood culture positive
Catheter site haemorrhage (bleeding at catheter site)
Catheter site infection (infection at the site of insertion)
Chest pain
Disease progression
Fluid overload (too much fluid in the blood)
Pulmonary arterial hypertension (high blood pressure in the arteries of lungs)
Pyrexia (fever)
Right ventricular failure (right half of the heart fails to work)
Septic shock (shock due to blood infection)

20-29:

n/a

30-39:

n/a

40-49:

Blood creatinine increased
Dyspnoea (difficult or laboured respiration)
Metabolic acidosis (body produces too much acid, or when the kidneys are not removing enough acid from the body)
Urine output decreased
Wheezing (a high-pitched whistling sound made while you breath)

50-59:

Fatigue (feeling of tiredness)
Fluid overload (too much fluid in the blood)
Headache (pain in head)
Hypervolaemia (abnormally increased volume of blood)
Hypokalaemia (low potassium)
Hypotension (abnormally low blood pressure)
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development)
Hypoxia (low oxygen in tissues)
Increased appetite
Infusion site pain

60+:

Anaemia (lack of blood)
Pneumonia
Malnutrition (a condition that results from eating a diet in which certain nutrients are lacking)
Renal failure acute (rapid kidney dysfunction)
Renal failure chronic (long lasting kidney dysfunction)
Respiratory failure (inadequate gas exchange by the respiratory system)
Sepsis (a severe blood infection that can lead to organ failure and death)
Shock (a life-threatening condition with symptoms like low blood pressure, weakness, shallow breathing, cold, clammy skin)
Subdural haematoma (blood collects between the skull and the surface of the brain)
Thrombocytopenia (decrease of platelets in blood)

What are the existing conditions these people have? *

Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 4 people, 23.53%
Wheezing (a high-pitched whistling sound made while you breath): 2 people, 11.76%
Nausea And Vomiting: 2 people, 11.76%
Dyspnea (difficult or laboured breathing): 2 people, 11.76%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 2 people, 11.76%
Seizures (abnormal excessive or synchronous neuronal activity in the brain): 1 person, 5.88%
Ovarian Cancer (cancer of ovary): 1 person, 5.88%
Non-Hodgkin's Lymphoma (malignant (cancer) cells form in the lymph system): 1 person, 5.88%
Constipation: 1 person, 5.88%

* Approximation only. Some reports may have incomplete information.

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