Ciprofloxacin and Zosyn drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Ciprofloxacin (ciprofloxacin) and Zosyn (piperacillin sodium; tazobactam sodium). Common drug interactions include injection site pain among females and renal tubular necrosis among males.

The phase IV clinical study analyzes what interactions people have when they take Ciprofloxacin and Zosyn. It is created by eHealthMe based on reports of 94 people who take the same drugs from the FDA, and is updated regularly.

What is Ciprofloxacin?

Ciprofloxacin has active ingredients of ciprofloxacin. It is often used in urinary tract infection. eHealthMe is studying from 22,256 Ciprofloxacin users. Check the latest studies of Ciprofloxacin.

What is Zosyn?

Zosyn has active ingredients of piperacillin sodium; tazobactam sodium. It is often used in pneumonia. eHealthMe is studying from 10,236 Zosyn users. Check the latest studies of Zosyn.

On Jul, 18, 2026

94 people who take Ciprofloxacin and Zosyn together, and have interactions are studied.

Ciprofloxacin and Zosyn drug interactions.

What are the common drug interactions of Ciprofloxacin and Zosyn, by gender? *:

female:

Injection site pain
Intra-abdominal haemorrhage (intra-abdominal bleeding)
Iron deficiency anaemia
Orthostatic hypotension (a medical condition consisting of a sudden decrease in blood pressure when a person stands up)
Pain
Renal failure (kidney dysfunction)
Sinusitis (inflammation of sinus)
Subcutaneous abscess
Torticollis (a twisted neck in which the head is tipped to one side, while the chin is turned to the other)
Urticaria (rash of round, red welts on the skin that itch intensely)

male:

Renal tubular necrosis (death of kidney tubules)
Tubulointerstitial nephritis (a form of nephritis affecting the interstitium of the kidneys surrounding the tubules)
Emotional distress
Cytokine release syndrome (immediate complication occurring with the use of anti-t cell antibody infusions)
Pyrexia (fever)
Anal abscess
Depression
Cellulitis (infection under the skin)
Desmoid tumour (fibrous tumour of muscle and connective tissue)
General physical health deterioration (weak health status)

What are the common drug interactions of Ciprofloxacin and Zosyn, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Anaemia (lack of blood)
Desmoid tumour (fibrous tumour of muscle and connective tissue)
Groin infection (infection in groin)
Necrotising fasciitis (an uncommon life-threatening soft-tissue infection)
Sepsis (a severe blood infection that can lead to organ failure and death)
Soft tissue infection
Anal abscess
Anxiety
Depression
Duodenal polyp (duodenal epithelial tumours)

30-39:

Chronic kidney disease
Anxiety
Emotional distress
Pain
Sepsis (a severe blood infection that can lead to organ failure and death)
Anal abscess
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Atrial thrombosis (blood clot that develops in an artery)
Cellulitis (infection under the skin)
Depression

40-49:

Renal tubular necrosis (death of kidney tubules)
Tubulointerstitial nephritis (a form of nephritis affecting the interstitium of the kidneys surrounding the tubules)
Enterocutaneous fistula
Renal failure (kidney dysfunction)
Drug ineffective
Subcutaneous abscess
Abscess (pus)
Abscess limb (limb infection)
Carbuncle (a carbuncle is an abscess larger than a boil)
Cellulitis (infection under the skin)

50-59:

Cardiac valve vegetation (heart valve abnormal growth)
Cellulitis (infection under the skin)
Cerebral arteriosclerosis (thickening and hardening of the walls of the arteries in the brain)
Cerebral infarction (less blood supply to brain resulting tissue damage)
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Decreased interest
Endocarditis bacterial (an inflammation of the inner layer of the heart by bacterial infection)
Epistaxis (bleed from the nose)
Fasciitis (infection of muscle surrounding tissue)
Gait disturbance

60+:

Acute sinusitis
Pain in extremity
Gallbladder enlargement
Gastroenteritis (inflammation of stomach and intestine)
Injection site pain
Intra-abdominal haemorrhage (intra-abdominal bleeding)
Iron deficiency anaemia
Orthostatic hypotension (a medical condition consisting of a sudden decrease in blood pressure when a person stands up)
Sinusitis (inflammation of sinus)
Torticollis (a twisted neck in which the head is tipped to one side, while the chin is turned to the other)

What are the existing conditions these people have? *

Type 2 Diabetes: 19 people, 20.21%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 16 people, 17.02%
High Blood Pressure: 15 people, 15.96%
Pneumonia: 13 people, 13.83%
Asthma: 12 people, 12.77%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 12 people, 12.77%
Pain: 12 people, 12.77%
Diverticulitis (digestive disease which involves the formation of pouches (diverticula) within the bowel wall): 12 people, 12.77%
Gastritis - Chronic (long lasting inflammation of stomach): 11 people, 11.70%
Sepsis (a severe blood infection that can lead to organ failure and death): 10 people, 10.64%

* Approximation only. Some reports may have incomplete information.

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