Clonidine and Brintellix drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Clonidine (clonidine) and Brintellix (vortioxetine hydrobromide). Common drug interactions include mania among females and headache among males.

The phase IV clinical study analyzes what interactions people have when they take Clonidine and Brintellix. It is created by eHealthMe based on reports of 44 people who take the same drugs from the FDA, and is updated regularly.

What is Clonidine?

Clonidine has active ingredients of clonidine. It is often used in high blood pressure. eHealthMe is studying from 65,645 Clonidine users. Check the latest studies of Clonidine.

What is Brintellix?

Brintellix has active ingredients of vortioxetine hydrobromide. It is often used in depression. eHealthMe is studying from 6,749 Brintellix users. Check the latest studies of Brintellix.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 04, 2026

44 people who take Clonidine and Brintellix together, and have interactions are studied.

Clonidine and Brintellix drug interactions.

What are the common drug interactions of Clonidine and Brintellix, by gender? *:

female:

Mania (a state of abnormally elevated or irritable mood)
Acne (skin problems that cause pimples)
Asthenia (weakness)
Coeliac disease (simple food intolerance)
Drug intolerance (drug sensitivity)
Ear infection
Essential tremor
Hyperhidrosis (abnormally increased sweating)
Nausea (feeling of having an urge to vomit)
Therapeutic response unexpected

male:

Headache (pain in head)
Malaise (a feeling of general discomfort or uneasiness)
Seasonal allergy (allergic condition due to certain season)
Sleep disorder
Spinal compression fracture (fracture due to spinal compression on bone)
Vomiting
Drug ineffective
Fall
Hunger
Joint injury

What are the common drug interactions of Clonidine and Brintellix, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Abnormal dreams
Drug ineffective
Hallucination, auditory (perceiving sounds without auditory stimulus)
Hallucination, visual (seeing things that aren't there)
Irritability
Myalgia (muscle pain)
Type 2 diabetes mellitus
Weight increased

20-29:

n/a

30-39:

Abdominal pain
Colitis ischaemic (due to infection of intestine impaired blood supply to colon)
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Haematemesis (vomiting of blood)
Oedema peripheral (superficial swelling)
Rectal haemorrhage (bleeding from anus)
Blood potassium decreased
Coagulopathy (blood's ability to clot is impaired)
Cough
Faecal incontinence (a lack of control over passing stool)

40-49:

Nausea (feeling of having an urge to vomit)
Abdominal discomfort
Tinnitus (a ringing in the ears)
Visual acuity reduced (reduced clearness of vision)
Visual field defect
Vomiting

50-59:

Dysphonia (speech disorder attributable to a disorder of phonation)
Headache (pain in head)
Lower limb fracture
Nasopharyngitis (inflammation of the nasopharynx)
Nausea (feeling of having an urge to vomit)
Shock (a life-threatening condition with symptoms like low blood pressure, weakness, shallow breathing, cold, clammy skin)

60+:

Headache (pain in head)
Malaise (a feeling of general discomfort or uneasiness)
Fall
Joint injury
Body height decreased
Nausea (feeling of having an urge to vomit)
Sleep disorder
Spinal compression fracture (fracture due to spinal compression on bone)
Vomiting

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 26 people, 59.09%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 19 people, 43.18%
Stress And Anxiety: 3 people, 6.82%
Major Depression (a mood state that goes well beyond temporarily feeling sad or blue. it is a serious medical illness that affects one's thoughts, feelings): 3 people, 6.82%
Insomnia (sleeplessness): 3 people, 6.82%
Hereditary Angioedema (recurrent episodes of severe swelling): 3 people, 6.82%

* Approximation only. Some reports may have incomplete information.

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