Clonidine and Roxanol drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Clonidine (clonidine) and Roxanol (morphine sulfate). Common drug interactions include oedema peripheral among females and constipation among males.

The phase IV clinical study analyzes what interactions people have when they take Clonidine and Roxanol. It is created by eHealthMe based on reports of 18 people who take the same drugs from the FDA, and is updated regularly.

What is Clonidine?

Clonidine has active ingredients of clonidine. It is often used in high blood pressure. eHealthMe is studying from 65,644 Clonidine users. Check the latest studies of Clonidine.

What is Roxanol?

Roxanol has active ingredients of morphine sulfate. eHealthMe is studying from 807 Roxanol users. Check the latest studies of Roxanol.

On Jul, 28, 2026

18 people who take Clonidine and Roxanol together, and have interactions are studied.

Clonidine and Roxanol drug interactions.

What are the common drug interactions of Clonidine and Roxanol, by gender? *:

female:

Oedema peripheral (superficial swelling)
Cellulitis (infection under the skin)
Deformity (disfigurement)
Erythema (redness of the skin)
Fatigue (feeling of tiredness)
Fibrosis (formation of excess fibrous connective tissue in an organ or tissue)
Joint range of motion decreased (disease of joint movement)
Joint stiffness
Mobility decreased (ability to move is reduced)
Musculoskeletal stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves)

male:

Constipation
Device failure
Neoplasm progression (growth of tumour)
Neurological decompensation (inability of brain to maintain proper function)
Peripheral swelling
T-cell depletion (less supply of t-cell by bone marrow)
Tumour haemorrhage (bleeding from tumour)
Unresponsive to stimuli
Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation)
Nerve injury

What are the common drug interactions of Clonidine and Roxanol, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Dyspnoea (difficult or laboured respiration)
Peripheral swelling

20-29:

n/a

30-39:

n/a

40-49:

Constipation
Device failure
Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation)
Nerve injury
Neuralgia (pain in one or more nerves)
Pain
Rash
Myasthenic syndrome (a group of conditions characterized by muscle weakness (myasthenia) that worsens with physical exertion)
Oedema peripheral (superficial swelling)
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)

50-59:

Cellulitis (infection under the skin)
Deformity (disfigurement)
Erythema (redness of the skin)
Fatigue (feeling of tiredness)
Fibrosis (formation of excess fibrous connective tissue in an organ or tissue)
Joint range of motion decreased (disease of joint movement)
Joint stiffness
Mobility decreased (ability to move is reduced)
Musculoskeletal stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves)
Nephrogenic systemic fibrosis (involves fibrosis of skin, joints, eyes due to kidney disease)

60+:

Abdominal pain
Asthenia (weakness)
Weight decreased
Cardiomegaly (increased size of heart than normal)
Chronic kidney disease
Dyspnoea (difficult or laboured respiration)
Nausea (feeling of having an urge to vomit)
Nephrogenic anaemia (anaemia due to kidney disease)
Pneumonia
Renal failure (kidney dysfunction)

What are the existing conditions these people have? *

Pain: 12 people, 66.67%
Stress And Anxiety: 10 people, 55.56%
Nausea (feeling of having an urge to vomit): 10 people, 55.56%
Depression: 10 people, 55.56%
Device Related Infection: 10 people, 55.56%
Gastritis Erosive (a break in the surface layer of the membrane lining the stomach with infection): 10 people, 55.56%
Herpes Zoster: 10 people, 55.56%
Itching: 10 people, 55.56%
High Blood Cholesterol: 10 people, 55.56%
Nuclear Magnetic Resonance Imaging Brain: 10 people, 55.56%

* Approximation only. Some reports may have incomplete information.

Do you take Clonidine and Roxanol?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously