Clopra and Hydrea drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Clopra (metoclopramide hydrochloride) and Hydrea (hydroxyurea). Common drug interactions include cardiac failure congestive among females and hyperbilirubinaemia among males.

The phase IV clinical study analyzes what interactions people have when they take Clopra and Hydrea. It is created by eHealthMe based on reports of 48 people who take the same drugs from the FDA, and is updated regularly.

What is Clopra?

Clopra has active ingredients of metoclopramide hydrochloride. eHealthMe is studying from 81,430 Clopra users. Check the latest studies of Clopra.

What is Hydrea?

Hydrea has active ingredients of hydroxyurea. It is often used in polycythemia vera. eHealthMe is studying from 9,083 Hydrea users. Check the latest studies of Hydrea.

On Jul, 11, 2026

48 people who take Clopra and Hydrea together, and have interactions are studied.

What are the common drug interactions of Clopra and Hydrea, by gender? *:

female:

Cardiac failure congestive
Disease progression
Disseminated intravascular coagulation (systemic activation of blood coagulation)
Encephalopathy (functioning of the brain is affected by some agent or condition)
Fall
Pyrexia (fever)
Renal failure acute (rapid kidney dysfunction)
General physical health deterioration (weak health status)
Septic shock (shock due to blood infection)
Aplasia (defective development or congenital absence of an organ or tissue)

male:

Hyperbilirubinaemia (excess of bilirubin in the blood)
Hypermagnesaemia (an electrolyte disturbance in which there is an abnormally elevated level of magnesium in the blood)
Sepsis (a severe blood infection that can lead to organ failure and death)
Squamous cell carcinoma (a cancer of a kind of epithelial cell)
Liver disorder (liver diseases)
Neutropenia (an abnormally low number of neutrophils)
Renal impairment (severely reduced kidney function)
Thrombocytopenia (decrease of platelets in blood)
Abdominal pain
Device related infection

What are the common drug interactions of Clopra and Hydrea, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Enterococcal sepsis
Hyperbilirubinaemia (excess of bilirubin in the blood)
Liver disorder (liver diseases)
Neutropenia (an abnormally low number of neutrophils)
Thrombocytopenia (decrease of platelets in blood)
Accidental exposure

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Abdominal pain
Arthralgia (joint pain)
Chest pain
Cough
Dizziness
Dizziness exertional
Dyspnoea (difficult or laboured respiration)
Fatigue (feeling of tiredness)
Haemoglobin decreased
Headache (pain in head)

50-59:

Hyperkalaemia (damage to or disease of the kidney)
Joint stiffness
Leukopenia (less number of white blood cells in blood)
Memory impairment
Palmar-plantar erythrodysaesthesia syndrome (hand-foot syndrome)
Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets)
Pyrexia (fever)
Rash
Thrombocytosis
Thyroid disorder (thyroid diseases)

60+:

Neutropenia (an abnormally low number of neutrophils)
Renal failure acute (rapid kidney dysfunction)
Acute myeloid leukaemia (acute cancer in which the bone marrow makes abnormal myeloblasts)
Thrombosis (formation of a blood clot inside a blood vessel)
Back pain
Cerebral haemorrhage (bleeding within the brain)
Chest pain
Confusional state
Diarrhoea
Ecchymosis (a discoloration of the skin resulting from bleeding underneath)

What are the existing conditions these people have? *

Acute Myeloid Leukaemia (acute cancer in which the bone marrow makes abnormal myeloblasts): 13 people, 27.08%
Nausea (feeling of having an urge to vomit): 12 people, 25.00%
High Blood Pressure: 8 people, 16.67%
Acute Leukaemia (blood cancer): 7 people, 14.58%
Hyperuricaemia (level of uric acid in the blood that is abnormally high): 5 people, 10.42%
Primary Myelofibrosis (primary disorder of the bone marrow): 5 people, 10.42%
Diarrhea: 5 people, 10.42%
Chronic Myeloid Leukaemia (long lasting type of cancer that starts in the blood-forming cells of the bone marrow and invades the blood): 4 people, 8.33%
Febrile Neutropenia (fever with reduced white blood cells): 4 people, 8.33%
Fever: 4 people, 8.33%

* Approximation only. Some reports may have incomplete information.

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