Clorazepate dipotassium and Topamax drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Clorazepate dipotassium (clorazepate dipotassium) and Topamax (topiramate). Common drug interactions include convulsion among females and vomiting among males.

The phase IV clinical study analyzes what interactions people have when they take Clorazepate dipotassium and Topamax. It is created by eHealthMe based on reports of 46 people who take the same drugs from the FDA, and is updated regularly.

What is Clorazepate dipotassium?

Clorazepate dipotassium has active ingredients of clorazepate dipotassium. It is often used in stress and anxiety. eHealthMe is studying from 2,708 Clorazepate dipotassium users. Check the latest studies of Clorazepate dipotassium.

What is Topamax?

Topamax has active ingredients of topiramate. It is often used in migraine. eHealthMe is studying from 58,954 Topamax users. Check the latest studies of Topamax.

On Jul, 08, 2026

46 people who take Clorazepate dipotassium and Topamax together, and have interactions are studied.

Clorazepate dipotassium and Topamax drug interactions.

What are the common drug interactions of Clorazepate Dipotassium and Topamax, by gender? *:

female:

Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Anticonvulsant drug level decreased
Rash
Adverse drug reaction
Diarrhoea
Gastrointestinal disorder (functional problems of gastrointestinal tract)
Headache (pain in head)
Hypothermia (body temperature drops below the required temperature for normal metabolism and body functions)
Abdominal pain
Atelectasis (partial or complete collapse of the lung)

male:

Vomiting
Diarrhoea
Aggression
Agitation (state of anxiety or nervous excitement)
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Constipation
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Diabetic coma
Diabetic ketoacidosis (diabetic ketoacidosis (dka) is high concentrations of ketone bodies)
Disease complication

What are the common drug interactions of Clorazepate Dipotassium and Topamax, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Vomiting
Diarrhoea
Seizure (abnormal excessive or synchronous neuronal activity in the brain)
Status epilepticus (a life-threatening condition in which the brain is in a state of persistent seizure)
Hypersomnia (excessive daytime sleepiness (eds))
Pyrexia (fever)
Gastroenteritis viral (inflammation of stomach and intestine caused by virus infection)
Hypoglycaemia (deficiency of glucose in the bloodstream)

10-19:

Anticonvulsant drug level decreased
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Blood carbon dioxide decreased
Blood chloride increased
Death
Hypokalaemia (low potassium)
Seizure (abnormal excessive or synchronous neuronal activity in the brain)

20-29:

Contusion (a type of hematoma of tissue in which capillaries)
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Cough
Diarrhoea
Disease complication
Dry skin
Hyperglycaemia (high blood sugar)
Obsessive-compulsive disorder (an anxiety disorder characterized by intrusive thoughts that produce uneasiness, apprehension, fear, or worry;)
Pancreatitis (inflammation of pancreas)

30-39:

Abdominal distension
Aggression
Agitation (state of anxiety or nervous excitement)
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Completed suicide (act of taking one's own life)
Constipation
Headache (pain in head)
Pancreatitis (inflammation of pancreas)
Rash
Respiratory tract infection

40-49:

Hepatitis cholestatic (flow of bile from the liver is slowed or blocked)
Type 2 diabetes mellitus
Depressed level of consciousness
Asthma
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Diabetes mellitus inadequate control
Diabetic coma
Diabetic ketoacidosis (diabetic ketoacidosis (dka) is high concentrations of ketone bodies)
Hepatitis (inflammation of the liver)

50-59:

n/a

60+:

Aortic stenosis (obstruction to the outflow of blood from the left ventricle into the aorta)
Calciphylaxis (is a syndrome with vascular calcium accumulation)
Metabolic encephalopathy (disorder or disease of the brain due to the body's disability to use energy)
Mitral valve incompetence (inefficient heart valve)
Renal failure (kidney dysfunction)
Sinus tachycardia (a heart rhythm with elevated rate of impulses originating from the sinoatrial node)
Cardiac failure congestive
Cerebral atrophy (decrement in size of brain)
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
Decubitus ulcer (a chronic ulcer of the skin caused by prolonged pressure on it)

What are the existing conditions these people have? *

Epilepsy (common and diverse set of chronic neurological disorders characterized by seizures): 6 people, 13.04%
Depression: 6 people, 13.04%
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body): 5 people, 10.87%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 4 people, 8.70%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 4 people, 8.70%
Constipation: 4 people, 8.70%
Asthma: 4 people, 8.70%
Wax Blockage: 3 people, 6.52%
Teething (process by which an infant's first teeth grows): 3 people, 6.52%
Seizures (abnormal excessive or synchronous neuronal activity in the brain): 3 people, 6.52%

* Approximation only. Some reports may have incomplete information.

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