Clozapine and Permax drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Clozapine (clozapine) and Permax (pergolide mesylate). Common drug interactions include venous thrombosis deep limb among females and aortic valve incompetence among males.

The phase IV clinical study analyzes what interactions people have when they take Clozapine and Permax. It is created by eHealthMe based on reports of 24 people who take the same drugs from the FDA, and is updated regularly.

What is Clozapine?

Clozapine has active ingredients of clozapine. It is often used in schizophrenia. eHealthMe is studying from 83,728 Clozapine users. Check the latest studies of Clozapine.

What is Permax?

Permax has active ingredients of pergolide mesylate. eHealthMe is studying from 1,532 Permax users. Check the latest studies of Permax.

On Jul, 20, 2026

24 people who take Clozapine and Permax together, and have interactions are studied.

What are the common drug interactions of Clozapine and Permax, by gender? *:

female:

Venous thrombosis deep limb (blood clot that forms in a vein deep in the limb)
Parkinson's disease
Death
Gamma-glutamyltransferase increased
Glucose tolerance impaired (blood glucose is raised beyond normal levels, but not high enough to warrant a diabetes diagnosis)
Hypothermia (body temperature drops below the required temperature for normal metabolism and body functions)
Pneumonia
Sepsis (a severe blood infection that can lead to organ failure and death)
Urinary tract infection

male:

Aortic valve incompetence
Oedema peripheral (superficial swelling)
Pneumonia
Renal failure (kidney dysfunction)
Obsessive-compulsive disorder (an anxiety disorder characterized by intrusive thoughts that produce uneasiness, apprehension, fear, or worry;)
Pathological gambling
Abnormal behaviour
Amyloidosis (a tumour within which amyloid is produced)
Anaemia (lack of blood)
Atelectasis (partial or complete collapse of the lung)

What are the common drug interactions of Clozapine and Permax, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Alanine aminotransferase increased
Personality change
Parkinson's disease
Parkinsonism (degenerative disorder of the central nervous system characterized by tremor and impaired muscular coordination)

50-59:

n/a

60+:

Aortic valve incompetence
Oedema peripheral (superficial swelling)
Abnormal behaviour
Cardiac ventricular disorder (ventricular dysfunction of heart)
Cardio-respiratory arrest (sudden dysfunction of heart and lungs)
Cholestasis (a condition where bile cannot flow from the liver to the duodenum)
Dehydration (dryness resulting from the removal of water)
Dyskinesia (abnormality or impairment of voluntary movement)
Glucose tolerance impaired (blood glucose is raised beyond normal levels, but not high enough to warrant a diabetes diagnosis)
Hip fracture

What are the existing conditions these people have? *

Parkinson's Disease: 7 people, 29.17%

* Approximation only. Some reports may have incomplete information.

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