Comtan and Ditropan drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Comtan (entacapone) and Ditropan (oxybutynin chloride). Common drug interactions include fall among females and haemorrhage among males.

The phase IV clinical study analyzes what interactions people have when they take Comtan and Ditropan. It is created by eHealthMe based on reports of 19 people who take the same drugs from the FDA, and is updated regularly.

What is Comtan?

Comtan has active ingredients of entacapone. It is often used in parkinson's disease. eHealthMe is studying from 3,979 Comtan users. Check the latest studies of Comtan.

What is Ditropan?

Ditropan has active ingredients of oxybutynin chloride. It is often used in urge incontinence. eHealthMe is studying from 11,799 Ditropan users. Check the latest studies of Ditropan.

On Jul, 12, 2026

19 people who take Comtan and Ditropan together, and have interactions are studied.

What are the common drug interactions of Comtan and Ditropan, by gender? *:

female:

Fall
Pyrexia (fever)
Confusional state
Creatinine renal clearance decreased
Eating disorder
Euphoric mood (excessively happy but may become angry or irritable)
Extrapyramidal disorder (involuntary muscle spasms in the face and neck)
Hallucination, olfactory (sensations of smelling something that is actually not there)
Hallucinations, mixed (sensations that appear real but are created by your mind -mixed)
Hypersexuality

male:

Haemorrhage (bleeding)
Weight decreased
Excessive skin
Hypotension (abnormally low blood pressure)
Malaise (a feeling of general discomfort or uneasiness)
Nasopharyngitis (inflammation of the nasopharynx)
Pain
Pallor
Purulence (containing pus)
Respiratory arrest (cessation of normal respiration due to failure of the lungs to function effectively)

What are the common drug interactions of Comtan and Ditropan, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

Device dislocation
Grand mal convulsion (a type of generalized seizure that affects the entire brain)
Weight decreased

60+:

Fall
Pyrexia (fever)
Blood creatinine increased
Blood pressure increased
Blood pressure systolic increased
Bradykinesia (decreased bodily movement. it is associated with basal ganglia diseases)
Coma (state of unconsciousness lasting more than six hours)
Confusion
Dizziness
Drug maladministration

What are the existing conditions these people have? *

Stress And Anxiety: 2 people, 10.53%
Pain: 2 people, 10.53%
Urinary Incontinence (inability to control the flow of urine and involuntary urination): 1 person, 5.26%
Schizophrenia (a mental disorder characterized by a breakdown of thought processes): 1 person, 5.26%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 1 person, 5.26%
Orthostatic Hypotension (a medical condition consisting of a sudden decrease in blood pressure when a person stands up): 1 person, 5.26%
High Blood Pressure: 1 person, 5.26%
Hallucinations (sensations that appear real but are created by your mind): 1 person, 5.26%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 1 person, 5.26%
Fever: 1 person, 5.26%

* Approximation only. Some reports may have incomplete information.

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