Comtan and Ramipril drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Comtan (entacapone) and Ramipril (ramipril). Common drug interactions include acute pulmonary oedema among females and agitation among males.

The phase IV clinical study analyzes what interactions people have when they take Comtan and Ramipril. It is created by eHealthMe based on reports of 12 people who take the same drugs from the FDA, and is updated regularly.

What is Comtan?

Comtan has active ingredients of entacapone. It is often used in parkinson's disease. eHealthMe is studying from 3,979 Comtan users. Check the latest studies of Comtan.

What is Ramipril?

Ramipril has active ingredients of ramipril. It is often used in high blood pressure. eHealthMe is studying from 147,397 Ramipril users. Check the latest studies of Ramipril.

On Jul, 21, 2026

12 people who take Comtan and Ramipril together, and have interactions are studied.

What are the common drug interactions of Comtan and Ramipril, by gender? *:

female:

Acute pulmonary oedema (sudden deposit of fluid in the lung))
Aortic valve incompetence
Cardiac failure acute
Cellulitis (infection under the skin)
Dyskinesia (abnormality or impairment of voluntary movement)
Infection
Mitral valve incompetence (inefficient heart valve)
Neutrophil count decreased (less than normal number of neutrophil a type of blood cell)
Neutrophil count increased (excess than normal number of neutrophil a type of blood cell)
White blood cell count decreased

male:

Agitation (state of anxiety or nervous excitement)
Pneumonia aspiration (bronchopneumonia that develops due to the entrance of foreign materials into the bronchial tree)
Dermatitis bullous (inflammation of the skin characterized by the presence of bullae which are filled with fluid)
Dysphagia (a condition in which swallowing is difficult or painful)
Hospitalisation
Inguinal hernia (hernia in which a loop of intestine enters the inguinal canal; the most common type of hernia in males)
Insomnia (sleeplessness)
Muscle fatigue (a condition in which muscles cannot exert their normal force)
Muscular weakness (muscle weakness)
Pemphigoid (tense blisters on the skin)

What are the common drug interactions of Comtan and Ramipril, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

n/a

60+:

Accelerated hypertension (significant hypertension)
Acute pulmonary oedema (sudden deposit of fluid in the lung))
Hallucination (an experience involving the perception of something not present)
Infection
Mitral valve incompetence (inefficient heart valve)
Muscle fatigue (a condition in which muscles cannot exert their normal force)
Muscular weakness (muscle weakness)
Neutrophil count decreased (less than normal number of neutrophil a type of blood cell)
Neutrophil count increased (excess than normal number of neutrophil a type of blood cell)
Pain

What are the existing conditions these people have? *

Respiratory Disorder (respiratory disease): 2 people, 16.67%
Back Pain: 2 people, 16.67%
Constipation: 1 person, 8.33%
Arrhythmia Supraventricular (irregular heartbeat supraventricular origin): 1 person, 8.33%
Arthritis (form of joint disorder that involves inflammation of one or more joints): 1 person, 8.33%
Cardiac Failure: 1 person, 8.33%
Chronic Obstructive Pulmonary Disease (a progressive disease that makes it hard to breathe): 1 person, 8.33%
Congestive Cardiomyopathy (weakening of heart muscle): 1 person, 8.33%
Deep Venous Thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis): 1 person, 8.33%
Psychotic Disorder Due To A General Medical Condition: 1 person, 8.33%

* Approximation only. Some reports may have incomplete information.

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