Contac and Acetaminophen drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Contac (chlorpheniramine maleate; phenylpropanolamine hydrochloride) and Acetaminophen (acetaminophen). Common drug interactions include cerebrovascular accident among females and abdominal pain among males.

The phase IV clinical study analyzes what interactions people have when they take Contac and Acetaminophen. It is created by eHealthMe based on reports of 14 people who take the same drugs from the FDA, and is updated regularly.

What is Contac?

Contac has active ingredients of chlorpheniramine maleate; phenylpropanolamine hydrochloride. eHealthMe is studying from 2,877 Contac users. Check the latest studies of Contac.

What is Acetaminophen?

Acetaminophen has active ingredients of acetaminophen. It is often used in pain. eHealthMe is studying from 183,077 Acetaminophen users. Check the latest studies of Acetaminophen.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 21, 2026

14 people who take Contac and Acetaminophen together, and have interactions are studied.

Contac and Acetaminophen drug interactions.

What are the common drug interactions of Contac and Acetaminophen, by gender? *:

female:

Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Anxiety
Injury
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Blood pressure increased
Fear of disease
Antibody test positive
Bladder dilatation
Blood pressure systolic increased
Breast cancer

male:

Abdominal pain
Abscess intestinal (collections of pus-intestinal)
Drug eruption (adverse drug reaction of the skin)
Drug rash with eosinophilia and systemic symptoms (adverse drug reactions with rash)
Gait disturbance
Large intestine perforation (hole in large intestine)
Measles (infectious viral disease causing fever and a red rash on the skin)
Oral mucosal erythema (redness of the mucous membrane of mouth)
Pyrexia (fever)
Skin exfoliation (removal of the oldest dead skin cells)

What are the common drug interactions of Contac and Acetaminophen, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Alanine aminotransferase increased
Aspartate aminotransferase increased
Blood lactate dehydrogenase increased
Conjunctival hyperaemia (congestion of conjunctival vessels)
Drug eruption (adverse drug reaction of the skin)
Drug rash with eosinophilia and systemic symptoms (adverse drug reactions with rash)
Measles (infectious viral disease causing fever and a red rash on the skin)
Oral mucosal erythema (redness of the mucous membrane of mouth)
Pyrexia (fever)
Skin exfoliation (removal of the oldest dead skin cells)

30-39:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Blood pressure increased
Breast cancer
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Fear of disease
Mood swings (an extreme or rapid change in mood)

40-49:

Abdominal pain
Abscess intestinal (collections of pus-intestinal)
Antibody test positive
Appendicitis perforated (perforated appendicitis is a condition in which an inflamed appendix bursts)
Bladder dilatation
Blood pressure systolic increased
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Depression
Haemorrhagic stroke (stroke caused by the rupture of a blood vessel in the brain)
Large intestine perforation (hole in large intestine)

50-59:

Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Hypertension (high blood pressure)
Anxiety
Convulsions (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled of muscles contract and relax rapidly and repeatedly)
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Injury
Transient ischaemic attack (a transient episode of neurologic dysfunction caused by ischemia (loss of blood flow))

60+:

n/a

What are the existing conditions these people have? *

Sinusitis (inflammation of sinus): 2 people, 14.29%
Renal Cell Carcinoma (a kidney cancer): 2 people, 14.29%
Nasopharyngitis (inflammation of the nasopharynx): 2 people, 14.29%
Muscle Aches (muscle pain): 2 people, 14.29%
High Blood Cholesterol: 2 people, 14.29%
Back Pain: 2 people, 14.29%
Weight Decreased: 1 person, 7.14%
Parkinson's Disease: 1 person, 7.14%
Irritable Bowel Syndrome: 1 person, 7.14%
Headache (pain in head): 1 person, 7.14%

* Approximation only. Some reports may have incomplete information.

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