Contrave and Melatonin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Contrave (bupropion hydrochloride; naltrexone hydrochloride) and Melatonin (melatonin). Common drug interactions include fatigue among females and atrioventricular block among males.

The phase IV clinical study analyzes what interactions people have when they take Contrave and Melatonin. It is created by eHealthMe based on reports of 21 people who take the same drugs from the FDA, and is updated regularly.

What is Contrave?

Contrave has active ingredients of bupropion hydrochloride; naltrexone hydrochloride. It is often used in weight loss. eHealthMe is studying from 5,553 Contrave users. Check the latest studies of Contrave.

What is Melatonin?

Melatonin has active ingredients of melatonin. It is often used in insomnia. eHealthMe is studying from 56,212 Melatonin users. Check the latest studies of Melatonin.

On Jul, 10, 2026

21 people who take Contrave and Melatonin together, and have interactions are studied.

Contrave and Melatonin drug interactions.

What are the common drug interactions of Contrave and Melatonin, by gender? *:

female:

Fatigue (feeling of tiredness)
Stress
Anxiety
Heart rate increased
Abnormal loss of weight
Chest wall mass
Decreased appetite
Diarrhoea
Dry mouth
Hunger

male:

Atrioventricular block (heart block)
Bradycardia (abnormally slow heart action)
Constipation
Dizziness
Vision blurred
Sleep apnoea syndrome (a sleep-related disorder in which the effort to breathe is diminished or absent)
Supraventricular tachycardia (rapid heart rhythm originating at or above the atrioventricular node)

What are the common drug interactions of Contrave and Melatonin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Hypersensitivity
Pain in jaw
Supraventricular tachycardia (rapid heart rhythm originating at or above the atrioventricular node)
Throat tightness

40-49:

Nausea (feeling of having an urge to vomit)
Anxiety
Heart rate irregular
Accident at work
Blood pressure increased
Breast cyst
Breast pain
Discomfort
Heart rate increased
Neck pain

50-59:

Drug ineffective
Food craving
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Hallucination (an experience involving the perception of something not present)
Headache (pain in head)
Hiatus hernia (hernia resulting from the protrusion of part of the stomach through the diaphragm)
Nausea (feeling of having an urge to vomit)
Vomiting
Weight increased
Hypertensive emergency

60+:

Atrioventricular block (heart block)
Bradycardia (abnormally slow heart action)
Somnolence (a state of near-sleep, a strong desire for sleep)
Constipation
Dizziness
Vision blurred
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development)
Joint stiffness
Rotator cuff syndrome (a spectrum of conditions affecting the rotator cuff tendons of the shoulder)

What are the existing conditions these people have? *

Weight Decreased: 5 people, 23.81%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 3 people, 14.29%
Nausea (feeling of having an urge to vomit): 2 people, 9.52%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 2 people, 9.52%
Migraine (headache): 2 people, 9.52%
Hypersensitivity: 2 people, 9.52%
Birth Control: 2 people, 9.52%

* Approximation only. Some reports may have incomplete information.

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