Corgard and Benadryl drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Corgard (nadolol) and Benadryl (diphenhydramine hydrochloride). Common drug interactions include gastrooesophageal reflux disease among females and dizziness among males.

The phase IV clinical study analyzes what interactions people have when they take Corgard and Benadryl. It is created by eHealthMe based on reports of 65 people who take the same drugs from the FDA, and is updated regularly.

What is Corgard?

Corgard has active ingredients of nadolol. It is often used in high blood pressure. eHealthMe is studying from 3,342 Corgard users. Check the latest studies of Corgard.

What is Benadryl?

Benadryl has active ingredients of diphenhydramine hydrochloride. It is often used in allergies. eHealthMe is studying from 104,954 Benadryl users. Check the latest studies of Benadryl.

On Jul, 14, 2026

65 people who take Corgard and Benadryl together, and have interactions are studied.

What are the common drug interactions of Corgard and Benadryl, by gender? *:

female:

Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Hot flush (sudden feelings of heat)
Hyperhidrosis (abnormally increased sweating)
Hypotension (abnormally low blood pressure)
Hypoventilation (too shallow or too slow breathing, which does not meet the needs of the body)
Impaired healing
Increased tendency to bruise (increased tendency to injure the underlying soft tissue or bone)
Influenza like illness
Infusion related reaction
Injection site erythema (redness at injection site)

male:

Dizziness
Confusion
Atherosclerosis (disorder of the arteries)
Blood magnesium decreased
Blood potassium decreased
Burning sensation
Cardiomyopathy (weakening of the heart muscle)
Dry skin
Dyspnoea (difficult or laboured respiration)
Eye irritation

What are the common drug interactions of Corgard and Benadryl, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Pain
Malaise (a feeling of general discomfort or uneasiness)
Bipolar disorder (mood disorder)
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Injury
Pain in extremity
Sleep disorder
Tremor (trembling or shaking movements in one or more parts of your body)
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)

40-49:

Anaemia (lack of blood)
Arthralgia (joint pain)
Burning sensation
Chills (felling of cold)
Decreased appetite
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Drug ineffective
Dry mouth
Dysmenorrhoea (painful menstruation)
Electrolyte imbalance

50-59:

Pain
Foot fracture
Mental disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability)
Osteopenia (a condition where bone mineral density is lower than normal)
Osteoporosis (bones weak and more likely to break)
Pain in extremity
Headache (pain in head)
Adenocarcinoma (malignant tumour formed from glandular structures in epithelial tissue)
Chronic kidney disease
Nausea (feeling of having an urge to vomit)

60+:

Deafness
Confusion
Back pain
Cardiac arrest
Cardiomyopathy (weakening of the heart muscle)
Chest discomfort
Decreased appetite
Dermatitis (inflammation of the skin resulting from direct irritation by an external agent or an allergic reaction to it)
Drug hypersensitivity
Drug ineffective

What are the existing conditions these people have? *

Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 17 people, 26.15%
Pain: 14 people, 21.54%
High Blood Cholesterol: 12 people, 18.46%
Hypersensitivity: 11 people, 16.92%
Multiple Myeloma (cancer of the plasma cells): 7 people, 10.77%
Headache (pain in head): 7 people, 10.77%
Urinary Tract Infection: 6 people, 9.23%
Cough: 6 people, 9.23%
Extrapyramidal Disorder (involuntary muscle spasms in the face and neck): 6 people, 9.23%
Multiple Allergies (allergy to multiple agents): 6 people, 9.23%

* Approximation only. Some reports may have incomplete information.

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