Cortef and Atrovent drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Cortef (hydrocortisone) and Atrovent (ipratropium bromide). Common drug interactions include candidiasis among females and headache among males.

The phase IV clinical study analyzes what interactions people have when they take Cortef and Atrovent. It is created by eHealthMe based on reports of 42 people who take the same drugs from the FDA, and is updated regularly.

What is Cortef?

Cortef has active ingredients of hydrocortisone. It is often used in addison's disease. eHealthMe is studying from 4,254 Cortef users. Check the latest studies of Cortef.

What is Atrovent?

Atrovent has active ingredients of ipratropium bromide. It is often used in chronic obstructive pulmonary disease. eHealthMe is studying from 33,210 Atrovent users. Check the latest studies of Atrovent.



On Jul, 26, 2026

42 people who take Cortef and Atrovent together, and have interactions are studied.

Cortef and Atrovent drug interactions.

What are the common drug interactions of Cortef and Atrovent, by gender? *:

female:

  1. Candidiasis (candidiasis or thrush is a fungal infection)
  2. Cardiac arrest
  3. Cardiac disorder
  4. Cardiac failure congestive
  5. Cardiomegaly (increased size of heart than normal)
  6. Cardiovascular disorder (heart diseases)
  7. Cellulitis (infection under the skin)
  8. Coagulopathy (blood's ability to clot is impaired)
  9. Coronary artery disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)
  10. Deafness

male:

  1. Headache (pain in head)
  2. Muscle strain (an injury to a muscle in which the muscle fibres tear)
  3. Malnutrition (a condition that results from eating a diet in which certain nutrients are lacking)
  4. Drug resistance (reduction in effectiveness of a drug)
  5. Migraine (headache)
  6. Prostate infection
  7. Decreased appetite
  8. Sepsis (a severe blood infection that can lead to organ failure and death)
  9. Weight decreased
  10. Abscess neck (neck abscesses)

What are the common drug interactions of Cortef and Atrovent, by age (0-1 to 60+)? *:

0-1:

  1. Decreased activity
  2. Fatigue (feeling of tiredness)

2-9:

n/a

10-19:

  1. Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
  2. Tachycardia (a heart rate that exceeds the range of 100 beats/min)
  3. Gastric infection (infection of stomach)
  4. Hypoglycaemia (deficiency of glucose in the bloodstream)
  5. Hyponatraemia (abnormally low level of sodium in the blood; associated with dehydration)
  6. Infusion site erythema (reddening of the skin at infusion site)
  7. Infusion site swelling

20-29:

  1. Anorexia nervosa (psychological disorder-eating disorder characterized by immoderate food restriction and irrational fear of gaining weight)
  2. Malnutrition (a condition that results from eating a diet in which certain nutrients are lacking)
  3. Weight decreased
  4. Weight increased

30-39:

  1. Alanine aminotransferase increased
  2. Aspartate aminotransferase increased
  3. Diarrhoea
  4. Fatigue (feeling of tiredness)
  5. Malignant neoplasm progression (cancer tumour came back)
  6. Renal failure (kidney dysfunction)

40-49:

  1. Fatigue (feeling of tiredness)
  2. Headache (pain in head)
  3. Abdominal pain
  4. Abdominal pain upper
  5. Aggression
  6. Asthenia (weakness)
  7. Back pain
  8. Bacterial infection
  9. Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
  10. Chills (felling of cold)

50-59:

  1. Cardiovascular disorder (heart diseases)
  2. Cellulitis (infection under the skin)
  3. Coagulopathy (blood's ability to clot is impaired)
  4. Coronary artery disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)
  5. Deafness
  6. Decreased appetite
  7. Dilatation ventricular
  8. Dysgeusia (disorder of the sense of taste)
  9. Dysphagia (a condition in which swallowing is difficult or painful)
  10. Ejection fraction decreased (systolic heart failure)

60+:

  1. Nausea (feeling of having an urge to vomit)
  2. Dyspnoea (difficult or laboured respiration)
  3. Vomiting
  4. Migraine (headache)
  5. Arthralgia (joint pain)
  6. Hypoglycaemia (deficiency of glucose in the bloodstream)
  7. Pain
  8. Drug resistance (reduction in effectiveness of a drug)
  9. Prostate infection
  10. Asthenia (weakness)

What are the existing conditions these people have? *

  1. Multiple Myeloma (cancer of the plasma cells): 11 people, 26.19%
  2. Hypercalcaemia Of Malignancy (elevated calcium (ca+) level in the blood with cancer): 11 people, 26.19%
  3. Immunodeficiency Common Variable: 9 people, 21.43%
  4. Hypercalcaemia (elevated calcium (ca+) level in the blood): 6 people, 14.29%
  5. Adrenal Insufficiency (a condition in which the adrenal glands do not produce adequate amounts of steroids): 4 people, 9.52%
  6. Restless Leg Syndrome (a powerful urge to move your legs): 3 people, 7.14%
  7. Muscle Strain (an injury to a muscle in which the muscle fibres tear): 3 people, 7.14%

* Approximation only. Some reports may have incomplete information.

Do you take Cortef and Atrovent?

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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Cortef and Atrovent:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Cortef:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Atrovent:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Cortef and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Atrovent and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

How the study uses the data?

The study uses data from the FDA. It is based on hydrocortisone and ipratropium bromide (the active ingredients of Cortef and Atrovent, respectively), and Cortef and Atrovent (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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