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Cortef and Ranexa drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Cortef (hydrocortisone) and Ranexa (ranolazine). Common drug interactions include diarrhoea among females and cardiac failure congestive among males.

The phase IV clinical study analyzes what interactions people have when they take Cortef and Ranexa. It is created by eHealthMe based on reports of 12 people who take the same drugs from the FDA, and is updated regularly.

What is Cortef?

Cortef has active ingredients of hydrocortisone. It is often used in addison's disease. eHealthMe is studying from 4,254 Cortef users. Check the latest studies of Cortef.

What is Ranexa?

Ranexa has active ingredients of ranolazine. It is often used in angina. eHealthMe is studying from 11,758 Ranexa users. Check the latest studies of Ranexa.

On Jul, 19, 2026

12 people who take Cortef and Ranexa together, and have interactions are studied.

Cortef and Ranexa drug interactions.

What are the common drug interactions of Cortef and Ranexa, by gender? *:

female:

  1. Diarrhoea
  2. Headache (pain in head)
  3. Injection site bruising
  4. Injection site haemorrhage (bleeding from injection site)
  5. Insomnia (sleeplessness)
  6. Nausea (feeling of having an urge to vomit)
  7. Odynophagia (painful swallowing, in the mouth (oropharynx) or oesophagus)
  8. Peripheral swelling
  9. Red blood cell count increased
  10. Rhinorrhoea (watery mucus discharge from the nose)

male:

  1. Cardiac failure congestive
  2. Pneumonia
  3. Cellulitis (infection under the skin)

What are the common drug interactions of Cortef and Ranexa, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

n/a

60+:

  1. Cardiac failure congestive
  2. Pneumonia
  3. Cellulitis (infection under the skin)
  4. Death
  5. Flatulence (flatus expelled through the anus)
  6. Influenza like illness
  7. Nodule (a growth of abnormal tissue)
  8. Renal failure (kidney dysfunction)
  9. Vomiting

What are the existing conditions these people have? *

  1. Hiatal Hernia (hernia resulting from the protrusion of part of the stomach through the diaphragm): 3 people, 25.00%
  2. Heart Attack: 3 people, 25.00%
  3. Blind Loop Syndrome (blind loop syndrome occurs when part of the intestine becomes bypassed): 3 people, 25.00%
  4. Blood Disorder: 3 people, 25.00%
  5. Cardiac Disorder: 3 people, 25.00%
  6. Diabetes: 3 people, 25.00%
  7. Diabetic Neuropathy (neuropathic disorders that are associated with diabetes mellitus): 3 people, 25.00%
  8. Fluid Retention (an abnormal accumulation of fluid in the blood): 3 people, 25.00%
  9. Angiopathy (generic term for a disease of the blood vessels): 3 people, 25.00%
  10. Hypersensitivity: 3 people, 25.00%

* Approximation only. Some reports may have incomplete information.

Do you take Cortef and Ranexa?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Cortef and Ranexa:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Cortef:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Ranexa:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Cortef and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Ranexa and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

How the study uses the data?

The study uses data from the FDA. It is based on hydrocortisone and ranolazine (the active ingredients of Cortef and Ranexa, respectively), and Cortef and Ranexa (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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