Cosopt and Centrum silver drug interactions - a phase IV clinical study of FDA data
Summary:
Drug interactions are reported among people who take Cosopt (dorzolamide hydrochloride; timolol maleate) and Centrum silver (ascorbic acid; biotin; cyanocobalamin; dexpanthenol; ergocalciferol; folic acid; niacinamide; pyridoxine hydrochloride; riboflavin phosphate sodium; thiamine hydrochloride; vitamin a; vitamin e). Common drug interactions include retinopathy among females and drug ineffective among males.
The phase IV clinical study analyzes what interactions people have when they take Cosopt and Centrum silver. It is created by eHealthMe based on reports of 50 people who take the same drugs from the FDA, and is updated regularly.
What is Cosopt?
Cosopt has active ingredients of dorzolamide hydrochloride; timolol maleate. It is often used in glaucoma. eHealthMe is studying from 9,029 Cosopt users. Check the latest studies of Cosopt.
What is Centrum silver?
Centrum silver has active ingredients of ascorbic acid; biotin; cyanocobalamin; dexpanthenol; ergocalciferol; folic acid; niacinamide; pyridoxine hydrochloride; riboflavin phosphate sodium; thiamine hydrochloride; vitamin a; vitamin e. It is often used in vitamin supplementation. eHealthMe is studying from 19,997 Centrum silver users. Check the latest studies of Centrum silver.
50 people who take Cosopt and Centrum silver together, and have interactions are studied.

What are the common drug interactions of Cosopt and Centrum Silver, by gender? *:
female:
- Retinopathy (acute damage to the retina of the eye)
- Swelling
- Tenderness (pain or discomfort when an affected area is touched)
- Thrombosis (formation of a blood clot inside a blood vessel)
- Tibia fracture (fracture of lower leg bone)
- Tooth infection
- Upper gastrointestinal haemorrhage (upper gastrointestinal bleeding)
- Urticaria (rash of round, red welts on the skin that itch intensely)
- Vision blurred
- Vitreous floaters (spots before the eyes)
male:
- Drug ineffective
- Febrile neutropenia (fever with reduced white blood cells)
- Blood glucose decreased
- Blood potassium increased
- Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
- Coeliac disease (simple food intolerance)
- Cough
- Dysgeusia (disorder of the sense of taste)
- Dysphagia (a condition in which swallowing is difficult or painful)
- Gastrointestinal hypermotility (over activity of the intestinal tract)
What are the common drug interactions of Cosopt and Centrum Silver, by age (0-1 to 60+)? *:
0-1:
n/a
2-9:
n/a
10-19:
n/a
20-29:
n/a
30-39:
n/a
40-49:
n/a
50-59:
- Rash pruritic (redness with itching)
60+:
- Anaemia (lack of blood)
- Asthenia (weakness)
- Carpal tunnel syndrome (nerve compression at wrist results numbness weakness, pain , swelling)
- Dementia (madness)
- Diarrhoea
- Febrile neutropenia (fever with reduced white blood cells)
- Flatulence (flatus expelled through the anus)
- Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
- Hypoacusis (loss of hearing)
- Hypoaesthesia (reduced sense of touch or sensation)
What are the existing conditions these people have? *
- Multiple Myeloma (cancer of the plasma cells): 16 people, 32.00%
- High Blood Cholesterol: 5 people, 10.00%
- Osteoporosis (bones weak and more likely to break): 4 people, 8.00%
- High Blood Pressure: 4 people, 8.00%
- Dry Eyes (lack of adequate tears): 4 people, 8.00%
- Stress And Anxiety: 3 people, 6.00%
- Acute Myeloid Leukaemia (acute cancer in which the bone marrow makes abnormal myeloblasts): 3 people, 6.00%
* Approximation only. Some reports may have incomplete information.
Do you take Cosopt and Centrum silver?
- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously
Related studies:
Effectiveness of, side effects of, and alternative drugs to the 2 drugs:
- Cosopt (9,029 reports)
- Centrum silver (19,997 reports)
Browse all drug interactions of Cosopt and Centrum silver:
a b c d e f g h i j k l m n o p q r s t u v w x y zSub-studies by gender and age:
Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+
Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+
Browse all side effects of Cosopt:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all side effects of Centrum silver:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all interactions between Cosopt and drugs from A to Z:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all interactions between Centrum silver and drugs from A to Z:
a b c d e f g h i j k l m n o p q r s t u v w x y zHow the study uses the data?
The study uses data from the FDA. It is based on dorzolamide hydrochloride; timolol maleate and ascorbic acid; biotin; cyanocobalamin; dexpanthenol; ergocalciferol; folic acid; niacinamide; pyridoxine hydrochloride; riboflavin phosphate sodium; thiamine hydrochloride; vitamin a; vitamin e (the active ingredients of Cosopt and Centrum silver, respectively), and Cosopt and Centrum silver (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.
How to use the study?
DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.
Who is eHealthMe?
With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).
WARNING, DISCLAIMER, USE FOR PUBLICATION
WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.
DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.
If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.
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