Methotrexate and Protropin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Methotrexate (methotrexate sodium) and Protropin (somatrem). Common drug interactions include t-cell lymphoma among females and lymphoproliferative disorder among males.

The phase IV clinical study analyzes what interactions people have when they take Methotrexate and Protropin. It is created by eHealthMe based on reports of 34 people who take the same drugs from the FDA, and is updated regularly.

What is Methotrexate?

Methotrexate has active ingredients of methotrexate sodium. It is often used in rheumatoid arthritis. eHealthMe is studying from 604,312 Methotrexate users. Check the latest studies of Methotrexate.

What is Protropin?

Protropin has active ingredients of somatrem. eHealthMe is studying from 394 Protropin users. Check the latest studies of Protropin.

On Jul, 04, 2026

34 people who take Methotrexate and Protropin together, and have interactions are studied.

Methotrexate and Protropin drug interactions.

What are the common drug interactions of Methotrexate and Protropin, by gender? *:

female:

T-cell lymphoma (a blood cell cancer)
Tachycardia (a heart rate that exceeds the range of 100 beats/min)
Thrombocytopenia (decrease of platelets in blood)
Hair follicle tumour benign
Lymphoproliferative disorder (a medical condition in which the immune system makes too many white blood cells)
Abdominal pain upper
Hepatosplenic t-cell lymphoma (neoplasm comprising medium-sized cytotoxic t-cells that show a significant sinusoidal infiltration in the liver, spleen, and bone marrow)
Hypotension (abnormally low blood pressure)
Pyrexia (fever)
Splenomegaly (enlargement of spleen)

male:

Lymphoproliferative disorder (a medical condition in which the immune system makes too many white blood cells)
Renal cell carcinoma (a kidney cancer)
Hair follicle tumour benign

What are the common drug interactions of Methotrexate and Protropin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Lymphoproliferative disorder (a medical condition in which the immune system makes too many white blood cells)
Hair follicle tumour benign
Thrombocytopenia (decrease of platelets in blood)
Renal cell carcinoma (a kidney cancer)
Abdominal pain upper
Hepatosplenic t-cell lymphoma (neoplasm comprising medium-sized cytotoxic t-cells that show a significant sinusoidal infiltration in the liver, spleen, and bone marrow)
Hypotension (abnormally low blood pressure)
Pyrexia (fever)
Splenomegaly (enlargement of spleen)
T-cell lymphoma (a blood cell cancer)

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

n/a

60+:

n/a

What are the existing conditions these people have? *

Polyarteritis Nodosa (progressive disease of connective tissue): 34 people, 100.00%
Juvenile Rheumatoid Arthritis (joint inflammation in children due to systemic disease): 17 people, 50.00%
Iridocyclitis (inflammation of the iris and ciliary body of the eye): 16 people, 47.06%

* Approximation only. Some reports may have incomplete information.

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