Cotrim and Ribavirin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Cotrim (sulfamethoxazole; trimethoprim) and Ribavirin (ribavirin). Common drug interactions include metabolic acidosis among females and pleural effusion among males.

The phase IV clinical study analyzes what interactions people have when they take Cotrim and Ribavirin. It is created by eHealthMe based on reports of 21 people who take the same drugs from the FDA, and is updated regularly.

What is Cotrim?

Cotrim has active ingredients of sulfamethoxazole; trimethoprim. eHealthMe is studying from 8,890 Cotrim users. Check the latest studies of Cotrim.

What is Ribavirin?

Ribavirin has active ingredients of ribavirin. It is often used in hepatitis c. eHealthMe is studying from 78,532 Ribavirin users. Check the latest studies of Ribavirin.

On Jul, 20, 2026

21 people who take Cotrim and Ribavirin together, and have interactions are studied.

What are the common drug interactions of Cotrim and Ribavirin, by gender? *:

female:

Metabolic acidosis (body produces too much acid, or when the kidneys are not removing enough acid from the body)
Nausea (feeling of having an urge to vomit)
Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets)
Pneumonia
Vertigo
Viral load increased
Vomiting
Weight decreased
Febrile neutropenia (fever with reduced white blood cells)
Anaemia (lack of blood)

male:

Pleural effusion (water on the lungs)
Pyrexia (fever)
Hepatosplenomegaly (enlargement of both the liver and the spleen)
Hypovolaemic shock (shock caused by severe blood or fluid loss)
Intestinal obstruction
Multi-organ failure (multisystem organ failure)
Peritonitis (inflammation of the peritoneum, the thin tissue that lines the inner wall of the abdomen and covers most of the abdominal organs)
Post procedural complication
Rectal abscess (pus in rectum)
Sepsis (a severe blood infection that can lead to organ failure and death)

What are the common drug interactions of Cotrim and Ribavirin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Febrile neutropenia (fever with reduced white blood cells)

10-19:

n/a

20-29:

Nausea (feeling of having an urge to vomit)
Palpitations (feelings or sensations that your heart is pounding or racing)
Pneumonia
Pyrexia (fever)
Subcutaneous haematoma (collection of blood outside the blood vessels on the skin)
Swelling
Tachycardia (a heart rate that exceeds the range of 100 beats/min)
Vomiting
Abdominal pain upper
Abnormal dreams

30-39:

Abdominal abscess (collection of pus in abdomen)
Abscess (pus)
Angioneurotic oedema (swelling that occurs just beneath the surface of the skin or mucous membranes)
Hepatosplenomegaly (enlargement of both the liver and the spleen)
Hypovolaemic shock (shock caused by severe blood or fluid loss)
Intestinal obstruction
Multi-organ failure (multisystem organ failure)
Peritonitis (inflammation of the peritoneum, the thin tissue that lines the inner wall of the abdomen and covers most of the abdominal organs)
Pleural effusion (water on the lungs)
Post procedural complication

40-49:

Ascites (accumulation of fluid in the abdominal cavity)
Asthenia (weakness)
Blood amylase increased
Candidiasis (candidiasis or thrush is a fungal infection)
Catheter site infection (infection at the site of insertion)
Cholangitis (infection of the bile duct)
Cytolytic hepatitis (dissolution or destruction of a liver cell)
Depression
Dizziness
Duodenitis (inflammation of the duodenum)

50-59:

Pericardial effusion (fluid around the heart)
Pyrexia (fever)
Acute myeloid leukaemia (acute cancer in which the bone marrow makes abnormal myeloblasts)
Asthenia (weakness)
Lower respiratory tract infection
Parainfluenzae virus infection
Pericardial haemorrhage (bleeding into the heart)
Pericarditis (inflammation of the pericardium)
Dermatitis allergic (inflammation of the skin due allergic reaction)
Areflexia (absence of a reflex)

60+:

Anaemia (lack of blood)
Decreased appetite
White blood cell count decreased

What are the existing conditions these people have? *

Pneumocystis Carinii Pneumonia (pneumonia occurring in infants or in persons with impaired immune systems): 3 people, 14.29%
Hepatitis E: 3 people, 14.29%
Chronic Lymphocytic Leukaemia (cancer in which the bone marrow makes too many lymphocytes (a type of white blood cell)): 3 people, 14.29%
Sedation: 2 people, 9.52%
Infection: 2 people, 9.52%
Hiv Infection: 2 people, 9.52%
Acute Myeloid Leukaemia (acute cancer in which the bone marrow makes abnormal myeloblasts): 2 people, 9.52%
Acute Graft Versus Host Disease (acute complication following an allogeneic tissue/blood transplant): 2 people, 9.52%

* Approximation only. Some reports may have incomplete information.

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