Creon and Probiotics drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Creon (pancrelipase (amylase;lipase;protease)) and Probiotics (yogurt). Common drug interactions include blood creatinine increased among females and diarrhoea among males.

The phase IV clinical study analyzes what interactions people have when they take Creon and Probiotics. It is created by eHealthMe based on reports of 98 people who take the same drugs from the FDA, and is updated regularly.

What is Creon?

Creon has active ingredients of pancrelipase (amylase;lipase;protease). It is often used in pancreatitis. eHealthMe is studying from 29,489 Creon users. Check the latest studies of Creon.

What is Probiotics?

Probiotics has active ingredients of yogurt. It is often used in irritable bowel syndrome. eHealthMe is studying from 9,541 Probiotics users. Check the latest studies of Probiotics.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 02, 2026

98 people who take Creon and Probiotics together, and have interactions are studied.

What are the common drug interactions of Creon and Probiotics, by gender? *:

female:

Blood creatinine increased
Blood glucose increased
Blood urea increased
Burning sensation
Deafness
Drug hypersensitivity
Drug intolerance (drug sensitivity)
Dyschezia (difficulty in defecating)
Ear infection
Feeding disorder (when children refuse to eat certain food groups)

male:

Diarrhoea
Weight decreased
Drug ineffective
Appetite disorder (abnormal eating habits)
Cerebral infarction (less blood supply to brain resulting tissue damage)
Dyspepsia (indigestion)
Endocarditis (inflammation in heart muscle)
Faeces discoloured
Fatigue (feeling of tiredness)
Febrile neutropenia (fever with reduced white blood cells)

What are the common drug interactions of Creon and Probiotics, by age (0-1 to 60+)? *:

0-1:

Langerhans' cell histiocytosis
Low birth weight baby
Maternal exposure before pregnancy (use of substance before pregnancy)
Maternal exposure during pregnancy (use of substance during pregnancy)
Premature baby
Strabismus (a disorder in which the two eyes do not line up in the same direction)

2-9:

n/a

10-19:

Pseudomonas infection (pseudomonas infection is caused by a bacterium, pseudomonas aeruginosa)

20-29:

Maternal exposure before pregnancy (use of substance before pregnancy)
Maternal exposure during pregnancy (use of substance during pregnancy)
Premature delivery
Twin pregnancy (two babies in uterus)

30-39:

Dyspnoea (difficult or laboured respiration)
Aphonia (inability to produce voice)
Cough
Cystic fibrosis (disease of the secretary glands)
Fatigue (feeling of tiredness)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Infection
Insomnia (sleeplessness)
Neuropathy peripheral (surface nerve damage)
Seasonal allergy (allergic condition due to certain season)

40-49:

Vomiting
Abdominal distension
Abdominal pain
Cystic fibrosis (disease of the secretary glands)
Decreased appetite
Diarrhoea
Dyspepsia (indigestion)
Eructation (release of gas from the digestive tract)
Flatulence (flatus expelled through the anus)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)

50-59:

Febrile neutropenia (fever with reduced white blood cells)
Chest discomfort
Coma (state of unconsciousness lasting more than six hours)
Depression
Dry skin
Fluid retention (an abnormal accumulation of fluid in the blood)
Hyperhidrosis (abnormally increased sweating)
Pneumonia
Productive cough
Skin discolouration (change of skin colour)

60+:

Diarrhoea
Fatigue (feeling of tiredness)
Alopecia (absence of hair from areas of the body)
Arthralgia (joint pain)
Death
Drug ineffective
Hair disorder
Multiple allergies (allergy to multiple agents)
Myalgia (muscle pain)
Nail disorder (disease of nail)

What are the existing conditions these people have? *

Short-Bowel Syndrome (a condition in which the body cannot absorb enough fluids and nutrients because part of the small intestine is missing): 8 people, 8.16%
Immunodeficiency Common Variable: 8 people, 8.16%
Cystic Fibrosis (disease of the secretary glands): 7 people, 7.14%
Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 6 people, 6.12%
Pain: 5 people, 5.10%

* Approximation only. Some reports may have incomplete information.

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