Cymbalta and Glucophage xr drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Cymbalta (duloxetine hydrochloride) and Glucophage xr (metformin hydrochloride). Common drug interactions include gingival swelling among females and insomnia among males.

The phase IV clinical study analyzes what interactions people have when they take Cymbalta and Glucophage xr. It is created by eHealthMe based on reports of 58 people who take the same drugs from the FDA, and is updated regularly.

What is Cymbalta?

Cymbalta has active ingredients of duloxetine hydrochloride. It is often used in depression. eHealthMe is studying from 154,973 Cymbalta users. Check the latest studies of Cymbalta.

What is Glucophage xr?

Glucophage xr has active ingredients of metformin hydrochloride. It is often used in diabetes. eHealthMe is studying from 3,939 Glucophage xr users. Check the latest studies of Glucophage xr.

On Jul, 05, 2026

58 people who take Cymbalta and Glucophage xr together, and have interactions are studied.

Cymbalta and Glucophage xr drug interactions.

What are the common drug interactions of Cymbalta and Glucophage Xr, by gender? *:

female:

Gingival swelling (gums swelling)
Gingivitis (inflammation of gums)
Haemorrhage (bleeding)
Headache (pain in head)
Insomnia (sleeplessness)
Jaw disorder (jaw disease)
Mouth ulceration (mouth ulcers)
Oral mucosal erythema (redness of the mucous membrane of mouth)
Osteomyelitis acute (rapid infection of bone)
Osteonecrosis (death of bone)

male:

Insomnia (sleeplessness)
Pain in extremity
Spinal fracture (fracture in one of vertebrae)
Sternal fracture
Burning sensation
Diabetic neuropathy (neuropathic disorders that are associated with diabetes mellitus)
Hyperglycaemia (high blood sugar)
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Polyneuropathy (neurological disorder that occurs when many peripheral nerves throughout the body malfunction simultaneously)
Actinic keratosis (skin disease due to sun exposure)

What are the common drug interactions of Cymbalta and Glucophage Xr, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Alopecia (absence of hair from areas of the body)
Blood glucose increased
Blood pressure increased
Diabetic neuropathy (neuropathic disorders that are associated with diabetes mellitus)
Dizziness
Dyspnoea (difficult or laboured respiration)
Fatigue (feeling of tiredness)
Hyperglycaemia (high blood sugar)
Neuropathy peripheral (surface nerve damage)
Pollakiuria (abnormally frequent passage of relatively small quantities or urine)

40-49:

Laryngitis (inflammation of the larynx)
Pain
Abscess (pus)
Necrotising fasciitis (an uncommon life-threatening soft-tissue infection)
Sepsis (a severe blood infection that can lead to organ failure and death)
Arthralgia (joint pain)
Asthenia (weakness)
Balance disorder
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Central nervous system lesion (an abnormality in tissue of brain or spinal cord)

50-59:

Spinal fracture (fracture in one of vertebrae)
Sternal fracture
Abdominal wall haematoma (abdominal wall blood clotting)
Beta haemolytic streptococcal infection (infection with streptococcus pyogenes, a beta-haemolytic bacterium cause mild to moderately severe respiratory tract, skin, and soft tissue)
Fatigue (feeling of tiredness)
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Osteomyelitis acute (rapid infection of bone)
Pneumonia
Pulmonary embolism (blockage of the main artery of the lung)
Pulmonary infarction (death of a small area of lung)

60+:

Rash
Arthralgia (joint pain)
Cataract (clouding of the lens inside the eye)
Chills (felling of cold)
Chronic kidney disease
Exostosis (formation of new bone on the surface of a bone)
Eye pain
Mean cell haemoglobin concentration decreased (less concentration of haemoglobin in a given volume of packed red blood cells)
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Ocular hyperaemia (an abnormally large amount of blood in eye)

What are the existing conditions these people have? *

Pain: 15 people, 25.86%
Type 2 Diabetes: 11 people, 18.97%
Nausea (feeling of having an urge to vomit): 8 people, 13.79%
Fibromyalgia (a long-term condition which causes pain all over the body): 7 people, 12.07%
Headache (pain in head): 7 people, 12.07%
High Blood Pressure: 7 people, 12.07%
Muscle Spasms (muscle contraction): 7 people, 12.07%
Stress And Anxiety: 6 people, 10.34%
Sleep Disorder: 6 people, 10.34%
Neuropathy Peripheral (surface nerve damage): 5 people, 8.62%

* Approximation only. Some reports may have incomplete information.

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