Daptomycin and Glucophage drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Daptomycin (daptomycin) and Glucophage (metformin hydrochloride). Common drug interactions include encephalopathy among males.

The phase IV clinical study analyzes what interactions people have when they take Daptomycin and Glucophage. It is created by eHealthMe based on reports of 22 people who take the same drugs from the FDA, and is updated regularly.

What is Daptomycin?

Daptomycin has active ingredients of daptomycin. eHealthMe is studying from 7,879 Daptomycin users. Check the latest studies of Daptomycin.

What is Glucophage?

Glucophage has active ingredients of metformin hydrochloride. It is often used in diabetes. eHealthMe is studying from 60,851 Glucophage users. Check the latest studies of Glucophage.



On Jul, 12, 2026

22 people who take Daptomycin and Glucophage together, and have interactions are studied.

Daptomycin and Glucophage drug interactions.

What are the common drug interactions of Daptomycin and Glucophage, by gender? *:

female:

n/a

male:

  1. Encephalopathy (functioning of the brain is affected by some agent or condition)
  2. Arrhythmia (irregular heartbeat)
  3. Hepatic failure (liver failure)
  4. Liver disorder (liver diseases)
  5. Pulmonary hypertension (increase in blood pressure in the lung artery)
  6. Renal failure acute (rapid kidney dysfunction)
  7. Septic shock (shock due to blood infection)
  8. Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
  9. Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
  10. Pneumonia

What are the common drug interactions of Daptomycin and Glucophage, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

  1. Encephalopathy (functioning of the brain is affected by some agent or condition)
  2. Arrhythmia (irregular heartbeat)
  3. Azotaemia (excess of urea or other nitrogenous compounds in the blood)
  4. Cardiac failure congestive
  5. Cardiac output decreased
  6. Cardiogenic shock (inadequate circulation of blood)
  7. Cerebellar ischaemia (lack of blood supply to cerebeller)
  8. Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
  9. Haematoma (collection of blood outside the blood vessels)
  10. Haemolysis (breaking open of red blood cells and the release of haemoglobin into the surrounding fluid)

60+:

  1. Hepatitis cholestatic (flow of bile from the liver is slowed or blocked)
  2. Interstitial lung disease
  3. Tremor (trembling or shaking movements in one or more parts of your body)
  4. Dyspnoea (difficult or laboured respiration)
  5. Malaise (a feeling of general discomfort or uneasiness)
  6. Platelet count decreased
  7. Rash
  8. Chills (felling of cold)
  9. Nausea (feeling of having an urge to vomit)
  10. Pyrexia (fever)

What are the existing conditions these people have? *

  1. Staphylococcal Sepsis (blood infection by an infection with staphylococcus bacteria): 3 people, 13.64%
  2. High Blood Pressure: 3 people, 13.64%
  3. Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 2 people, 9.09%
  4. Hyperlipidaemia (presence of excess lipids in the blood): 2 people, 9.09%
  5. Device Related Infection: 2 people, 9.09%
  6. Coronary Heart Disease (narrowing or blockage of the coronary arteries): 2 people, 9.09%
  7. Cardiac Failure Congestive: 2 people, 9.09%

* Approximation only. Some reports may have incomplete information.

Do you take Daptomycin and Glucophage?

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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Daptomycin and Glucophage:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Daptomycin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Glucophage:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Daptomycin and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Glucophage and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Related publications that referenced our studies


How the study uses the data?

The study uses data from the FDA. It is based on daptomycin and metformin hydrochloride (the active ingredients of Daptomycin and Glucophage, respectively), and Daptomycin and Glucophage (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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