Daptomycin and Rifaximin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Daptomycin (daptomycin) and Rifaximin (rifaximin). Common drug interactions include coma among females and drug hypersensitivity among males.

The phase IV clinical study analyzes what interactions people have when they take Daptomycin and Rifaximin. It is created by eHealthMe based on reports of 27 people who take the same drugs from the FDA, and is updated regularly.

What is Daptomycin?

Daptomycin has active ingredients of daptomycin. eHealthMe is studying from 7,879 Daptomycin users. Check the latest studies of Daptomycin.

What is Rifaximin?

Rifaximin has active ingredients of rifaximin. eHealthMe is studying from 3,597 Rifaximin users. Check the latest studies of Rifaximin.

On Jul, 10, 2026

27 people who take Daptomycin and Rifaximin together, and have interactions are studied.

Daptomycin and Rifaximin drug interactions.

What are the common drug interactions of Daptomycin and Rifaximin, by gender? *:

female:

Coma (state of unconsciousness lasting more than six hours)
Lactic acidosis (low ph in body tissues)
Urinary tract infection
Small intestinal obstruction (blockage in small intestine)
Drug ineffective
Haematuria (presence of blood in urine)
Acinetobacter infection (infection by group of bacteria commonly found in soil and water)
Acute respiratory distress syndrome
Anaemia (lack of blood)
Cardiovascular disorder (heart diseases)

male:

Drug hypersensitivity
Cough
Blood creatinine increased
Cardiac arrest
Dysphagia (a condition in which swallowing is difficult or painful)
Hepatic encephalopathy (spectrum of neuropsychiatric abnormalities in patients with liver failure)
Hepatic failure (liver failure)
Hepatic ischaemia (liver does not get enough blood or oxygen, causing injury to liver cells)
Hepatotoxicity (chemical-driven liver damage)
Hyperammonaemia

What are the common drug interactions of Daptomycin and Rifaximin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Device related infection

10-19:

n/a

20-29:

n/a

30-39:

Coma (state of unconsciousness lasting more than six hours)
Lactic acidosis (low ph in body tissues)
Hypokalaemia (low potassium)
Pancreatitis acute (sudden inflammation of pancreas)
Urinary tract infection
Venous thrombosis limb (blood clot that forms in a vein in the limb)

40-49:

Hyperammonaemia
Stasis syndrome (overgrowth of bacteria in the small intestine secondary to various disorders causing stasis; it is characterized by malabsorption of vitamin b12, steatorrhea, and anaemia)

50-59:

Drug hypersensitivity
Jugular vein thrombosis (clot in jugular vein)
Device related infection
Drug ineffective
Acinetobacter infection (infection by group of bacteria commonly found in soil and water)
Acute respiratory distress syndrome
Anaemia (lack of blood)
Cardiac arrest
Cardiovascular disorder (heart diseases)
Disseminated intravascular coagulation (systemic activation of blood coagulation)

60+:

Cough
Crepitations (noises are produced by the rubbing of parts one against the other)
Blood creatinine increased
Dysphagia (a condition in which swallowing is difficult or painful)
Hepatic encephalopathy (spectrum of neuropsychiatric abnormalities in patients with liver failure)
Hepatotoxicity (chemical-driven liver damage)
Drug ineffective
Dyspnoea (difficult or laboured respiration)
Eosinophilic pneumonia acute (eosinophil accumulates in the lung-acute)
Hypoxia (low oxygen in tissues)

What are the existing conditions these people have? *

Short-Bowel Syndrome (a condition in which the body cannot absorb enough fluids and nutrients because part of the small intestine is missing): 18 people, 66.67%
Device Related Infection: 9 people, 33.33%
Staphylococcal Infection (an infection with staphylococcus bacteria): 9 people, 33.33%
Urinary Tract Infection: 8 people, 29.63%
Infection: 6 people, 22.22%
Depression: 6 people, 22.22%
Rickets (softening of bones): 6 people, 22.22%
Pain: 6 people, 22.22%
Nausea (feeling of having an urge to vomit): 5 people, 18.52%
Klebsiella Infection: 4 people, 14.81%

* Approximation only. Some reports may have incomplete information.

Do you take Daptomycin and Rifaximin?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously