Definity and Topamax drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Definity (perflutren) and Topamax (topiramate). Common drug interactions include dyspnoea among females and headache among males.

The phase IV clinical study analyzes what interactions people have when they take Definity and Topamax. It is created by eHealthMe based on reports of 19 people who take the same drugs from the FDA, and is updated regularly.

What is Definity?

Definity has active ingredients of perflutren. eHealthMe is studying from 4,853 Definity users. Check the latest studies of Definity.

What is Topamax?

Topamax has active ingredients of topiramate. It is often used in migraine. eHealthMe is studying from 58,954 Topamax users. Check the latest studies of Topamax.

On Jul, 09, 2026

19 people who take Definity and Topamax together, and have interactions are studied.

What are the common drug interactions of Definity and Topamax, by gender? *:

female:

Dyspnoea (difficult or laboured respiration)
Headache (pain in head)
Muscle spasms (muscle contraction)
Nausea (feeling of having an urge to vomit)
Anxiety
Blood pressure increased
Flank pain (a distressing sensation experienced around the lower back and the upper abdomen)
Neck pain
Pain in extremity
Arrhythmia (irregular heartbeat)

male:

Headache (pain in head)
Blood pressure increased
Erythema (redness of the skin)
Hypoaesthesia (reduced sense of touch or sensation)
Back pain
Coccydynia (pain in the coccyx or tailbone area)
Neck pain
Spinal pain (pain in spine)

What are the common drug interactions of Definity and Topamax, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Dyspnoea (difficult or laboured respiration)

30-39:

n/a

40-49:

Back pain
Erythema (redness of the skin)
Chest pain
Muscle spasms (muscle contraction)
Neck pain
Pain in extremity
Blood pressure increased
Headache (pain in head)
Hypoaesthesia (reduced sense of touch or sensation)
Anxiety

50-59:

Back pain
Blood pressure increased
Breast pain
Chest pain
Cough
Headache (pain in head)
Muscle spasms (muscle contraction)
Neck pain
Pain
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)

60+:

Headache (pain in head)
Back pain
Musculoskeletal pain (pain affects the bones, muscles, ligaments, tendons, and nerves)
Seizure like phenomena (a variety of medical conditions may produce sudden episodes which have some similarities to epileptic seizures)
Spinal pain (pain in spine)
Wheezing (a high-pitched whistling sound made while you breath)
Nausea (feeling of having an urge to vomit)
Anxiety
Blood pressure increased
Chest pain

What are the existing conditions these people have? *

Back Pain: 1 person, 5.26%
Asthma: 1 person, 5.26%

* Approximation only. Some reports may have incomplete information.

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