Definity and Zetia drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Definity (perflutren) and Zetia (ezetimibe). Common drug interactions include back pain among females and back pain among males.

The phase IV clinical study analyzes what interactions people have when they take Definity and Zetia. It is created by eHealthMe based on reports of 39 people who take the same drugs from the FDA, and is updated regularly.

What is Definity?

Definity has active ingredients of perflutren. eHealthMe is studying from 4,853 Definity users. Check the latest studies of Definity.

What is Zetia?

Zetia has active ingredients of ezetimibe. It is often used in high blood cholesterol. eHealthMe is studying from 49,113 Zetia users. Check the latest studies of Zetia.



On Aug, 05, 2026

39 people who take Definity and Zetia together, and have interactions are studied.

Definity and Zetia drug interactions.

What are the common drug interactions of Definity and Zetia, by gender? *:

female:

  1. Back pain
  2. Muscle spasms (muscle contraction)
  3. Anxiety
  4. Arthralgia (joint pain)
  5. Burning sensation
  6. Chest discomfort
  7. Chest pain
  8. Coccydynia (pain in the coccyx or tailbone area)
  9. Dyspnoea (difficult or laboured respiration)
  10. Dyspnoea exertional (breathlessness or shortness of breath)

male:

  1. Back pain
  2. Pain in extremity
  3. Drug ineffective
  4. Dyspnoea (difficult or laboured respiration)
  5. Flushing (the warm, red condition of human skin)
  6. Lip swelling
  7. Muscle spasms (muscle contraction)
  8. Abdominal pain
  9. Apnoea (suspension of external breathing)
  10. Blood pressure decreased

What are the common drug interactions of Definity and Zetia, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

  1. Back pain
  2. Chest pain

50-59:

  1. Back pain
  2. Arthralgia (joint pain)
  3. Flushing (the warm, red condition of human skin)
  4. Headache (pain in head)
  5. Muscle spasms (muscle contraction)
  6. Oropharyngeal pain
  7. Pain in extremity
  8. Throat tightness
  9. Urticaria (rash of round, red welts on the skin that itch intensely)

60+:

  1. Back pain
  2. Muscle spasms (muscle contraction)
  3. Thrombocytopenia (decrease of platelets in blood)
  4. Drug ineffective
  5. Lip swelling
  6. Vomiting
  7. Abdominal pain
  8. Anxiety
  9. Apnoea (suspension of external breathing)
  10. Arthralgia (joint pain)

* Approximation only. Some reports may have incomplete information.

Do you take Definity and Zetia?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously



Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Definity and Zetia:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Definity:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Zetia:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Definity and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Zetia and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

How the study uses the data?

The study uses data from the FDA. It is based on perflutren and ezetimibe (the active ingredients of Definity and Zetia, respectively), and Definity and Zetia (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.



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