Depakote er and Levaquin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Depakote er (divalproex sodium) and Levaquin (levofloxacin). Common drug interactions include pain in extremity among females and anxiety among males.

The phase IV clinical study analyzes what interactions people have when they take Depakote er and Levaquin. It is created by eHealthMe based on reports of 21 people who take the same drugs from the FDA, and is updated regularly.

What is Depakote er?

Depakote er has active ingredients of divalproex sodium. It is often used in bipolar disorder. eHealthMe is studying from 6,042 Depakote er users. Check the latest studies of Depakote er.

What is Levaquin?

Levaquin has active ingredients of levofloxacin. It is often used in sinusitis. eHealthMe is studying from 56,638 Levaquin users. Check the latest studies of Levaquin.

On Jul, 27, 2026

21 people who take Depakote er and Levaquin together, and have interactions are studied.

Depakote er and Levaquin drug interactions.

What are the common drug interactions of Depakote Er and Levaquin, by gender? *:

female:

Pain in extremity
Tremor (trembling or shaking movements in one or more parts of your body)
Abdominal pain upper
Asthenia (weakness)
Dehydration (dryness resulting from the removal of water)
Dyspepsia (indigestion)
Gait disturbance
Haematemesis (vomiting of blood)
Nausea (feeling of having an urge to vomit)
Oedema peripheral (superficial swelling)

male:

Anxiety
Dizziness
Fatigue (feeling of tiredness)
Granulocytopenia (lack of granulocyte)

What are the common drug interactions of Depakote Er and Levaquin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Cholecystitis chronic (long lasting infection of gallbladder)
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Vomiting
Abdominal pain upper
Dyspepsia (indigestion)
Haematemesis (vomiting of blood)
Arthralgia (joint pain)
Back pain
Bone pain
Cystitis (inflammation of the wall of the bladder)

30-39:

Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Pancreatitis (inflammation of pancreas)
Type 2 diabetes mellitus

40-49:

Anxiety
Dizziness
Fatigue (feeling of tiredness)
Accident
Blood cholesterol increased
Blood triglycerides increased
Hyperglycaemia (high blood sugar)
Insulin resistance
Irritable bowel syndrome
Obesity (having too much body fat)

50-59:

Dehydration (dryness resulting from the removal of water)
Diarrhoea
Drug ineffective
Dyspnoea (difficult or laboured respiration)
Emotional disorder
Fatigue (feeling of tiredness)
Gait disturbance
Haematochezia (passage of stools containing blood)
Haemoptysis (blood-stained sputum from the bronchi, larynx, trachea, or lungs)
Hallucination (an experience involving the perception of something not present)

60+:

Abnormal behaviour
Confusional state
Fall
Haematoma (collection of blood outside the blood vessels)
International normalised ratio increased
Upper limb fracture

What are the existing conditions these people have? *

Pain: 9 people, 42.86%
Birth Control: 6 people, 28.57%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 3 people, 14.29%
Schizoaffective Disorder (a mental disorder characterized by disordered thought): 2 people, 9.52%
Pneumonia: 2 people, 9.52%
Nausea (feeling of having an urge to vomit): 2 people, 9.52%
Epilepsy (common and diverse set of chronic neurological disorders characterized by seizures): 2 people, 9.52%
Depression: 2 people, 9.52%
Back Pain: 2 people, 9.52%

* Approximation only. Some reports may have incomplete information.

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