Depo-medrol and Xarelto drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Depo-medrol (methylprednisolone acetate) and Xarelto (rivaroxaban). Common drug interactions include anaemia among females and alcohol abuse among males.

The phase IV clinical study analyzes what interactions people have when they take Depo-medrol and Xarelto. It is created by eHealthMe based on reports of 14 people who take the same drugs from the FDA, and is updated regularly.

What is Depo-medrol?

Depo-medrol has active ingredients of methylprednisolone acetate. It is often used in birth control. eHealthMe is studying from 5,933 Depo-medrol users. Check the latest studies of Depo-medrol.

What is Xarelto?

Xarelto has active ingredients of rivaroxaban. It is often used in atrial fibrillation/flutter. eHealthMe is studying from 212,377 Xarelto users. Check the latest studies of Xarelto.

On Jul, 21, 2026

14 people who take Depo-medrol and Xarelto together, and have interactions are studied.

Depo-medrol and Xarelto drug interactions.

What are the common drug interactions of Depo-Medrol and Xarelto, by gender? *:

female:

Anaemia (lack of blood)
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Blood pressure increased
Diarrhoea
Febrile neutropenia (fever with reduced white blood cells)
Hypokalaemia (low potassium)
Micturition urgency (urgency to pass the urine)
Neutrophil count decreased (less than normal number of neutrophil a type of blood cell)
Platelet count decreased
White blood cell count decreased

male:

Alcohol abuse
Anger
Drug dependence
Drug ineffective
Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation)
Dyspnoea exertional (breathlessness or shortness of breath)
Fatigue (feeling of tiredness)
Haemorrhagic disorder (bleeding disorder)
Hyperlipidaemia (presence of excess lipids in the blood)
Insomnia (sleeplessness)

What are the common drug interactions of Depo-Medrol and Xarelto, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Anaemia (lack of blood)
Febrile neutropenia (fever with reduced white blood cells)
Hypokalaemia (low potassium)
Neutrophil count decreased (less than normal number of neutrophil a type of blood cell)
Platelet count decreased
White blood cell count decreased

50-59:

Fatigue (feeling of tiredness)
Muscle spasms (muscle contraction)
Post procedural hypothyroidism
Quality of life decreased

60+:

Alcohol abuse
Anger
Drug dependence
Drug ineffective
Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation)
Dyspnoea (difficult or laboured respiration)
Dyspnoea exertional (breathlessness or shortness of breath)
Fatigue (feeling of tiredness)
Haemorrhagic disorder (bleeding disorder)
Hyperlipidaemia (presence of excess lipids in the blood)

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 6 people, 42.86%
Pain: 2 people, 14.29%
Hypocalcaemia (levels of calcium in blood serum are abnormally low): 2 people, 14.29%
White Blood Cell Count Increased: 1 person, 7.14%
Flatulence (flatus expelled through the anus): 1 person, 7.14%
Agranulocytosis (a deficiency of granulocytes in the blood, causing increased vulnerability to infection): 1 person, 7.14%
Arrhythmias (irregular heartbeat): 1 person, 7.14%
Ascites (accumulation of fluid in the abdominal cavity): 1 person, 7.14%
Back Pain: 1 person, 7.14%
Bone Pain: 1 person, 7.14%

* Approximation only. Some reports may have incomplete information.

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