Depo-provera and Colace drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Depo-provera (medroxyprogesterone acetate) and Colace (docusate ). Common drug interactions include lymphopenia among females and fall among males.

The phase IV clinical study analyzes what interactions people have when they take Depo-provera and Colace. It is created by eHealthMe based on reports of 62 people who take the same drugs from the FDA, and is updated regularly.

What is Depo-provera?

Depo-provera has active ingredients of medroxyprogesterone acetate. It is often used in birth control. eHealthMe is studying from 17,093 Depo-provera users. Check the latest studies of Depo-provera.

What is Colace?

Colace has active ingredients of docusate . It is often used in constipation. eHealthMe is studying from 41,841 Colace users. Check the latest studies of Colace.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 02, 2026

62 people who take Depo-provera and Colace together, and have interactions are studied.

Depo-provera and Colace drug interactions.

What are the common drug interactions of Depo-Provera and Colace, by gender? *:

female:

Lymphopenia (an abnormally low level of lymphocytes in the blood)
Maternal exposure during pregnancy (use of substance during pregnancy)
Mental status changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation)
Multiple sclerosis relapse (reoccurrence of a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)
Neutrophilia
Normal newborn
Pruritus (severe itching of the skin)
Pulmonary arterial pressure increased
Pulmonary embolism (blockage of the main artery of the lung)
Pulmonary oedema (fluid accumulation in the lungs)

male:

Fall
Multiple sclerosis relapse (reoccurrence of a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)
Dysarthria (speech disorder)
Dyspnoea (difficult or laboured respiration)
Gait disturbance
Gastrointestinal disorder (functional problems of gastrointestinal tract)
Injection site reaction
Intentional self-injury
Leukocytosis (increased white blood cells)
Limb injury

What are the common drug interactions of Depo-Provera and Colace, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Hospitalisation
Hypertension (high blood pressure)
Hypotension (abnormally low blood pressure)
Iron deficiency anaemia
Tachycardia (a heart rate that exceeds the range of 100 beats/min)
Anaemia (lack of blood)
Occult blood positive
Anaemia vitamin b12 deficiency
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Abdominal mass (localized enlargement or swelling in the human abdomen)

20-29:

Nausea (feeling of having an urge to vomit)
Fatigue (feeling of tiredness)
Dizziness
Pain
Chest pain
Decreased appetite
Dyspnoea (difficult or laboured respiration)
Fluid overload (too much fluid in the blood)
Gait disturbance
Pulmonary arterial hypertension (high blood pressure in the arteries of lungs)

30-39:

Spinal fracture (fracture in one of vertebrae)
Staphylococcal bacteraemia (a bacterial infection of blood)
Tachypnoea (a condition of rapid breathing over 20 per minute)
Thirst
Thrombocytopenia (decrease of platelets in blood)
Depression
Cerebellar atrophy (degeneration of the section of the brain responsible for balance, voluntary muscle movements)
Contusion (a type of hematoma of tissue in which capillaries)
Fall
Gliomatosis cerebri (a rare brain cancer that is highly aggressive and very resistant to treatment)

40-49:

Fall
Multiple sclerosis relapse (reoccurrence of a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)
Pain
Blindness
Cellulitis (infection under the skin)
Cognitive disorder (mental health disorders affects learning, memory, perception, and problem solving)
Decubitus ulcer (a chronic ulcer of the skin caused by prolonged pressure on it)
Device related infection
Fatigue (feeling of tiredness)
Furuncle (infection of the hair follicle)

50-59:

Anaemia (lack of blood)
Application site rash
Blood alkaline phosphatase increased
Drug-induced liver injury (diseases of the liver that are caused by physician-prescribed medications)
Gastric bypass
Granulocytopenia (lack of granulocyte)
Headache (pain in head)
Leukopenia (less number of white blood cells in blood)
Pruritus (severe itching of the skin)

60+:

Myalgia (muscle pain)

What are the existing conditions these people have? *

Pain: 11 people, 17.74%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 11 people, 17.74%
Stress And Anxiety: 7 people, 11.29%
Chronic Renal Failure (kidney failure): 5 people, 8.06%
Pulmonary Hypertension (increase in blood pressure in the lung artery): 4 people, 6.45%
Nausea (feeling of having an urge to vomit): 4 people, 6.45%
Anaemia (lack of blood): 4 people, 6.45%

* Approximation only. Some reports may have incomplete information.

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