Depo-provera and Hydroxyurea drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Depo-provera (medroxyprogesterone acetate) and Hydroxyurea (hydroxyurea). Common drug interactions include diarrhoea among females.

The phase IV clinical study analyzes what interactions people have when they take Depo-provera and Hydroxyurea. It is created by eHealthMe based on reports of 19 people who take the same drugs from the FDA, and is updated regularly.

What is Depo-provera?

Depo-provera has active ingredients of medroxyprogesterone acetate. It is often used in birth control. eHealthMe is studying from 17,093 Depo-provera users. Check the latest studies of Depo-provera.

What is Hydroxyurea?

Hydroxyurea has active ingredients of hydroxyurea. It is often used in polycythemia vera. eHealthMe is studying from 17,240 Hydroxyurea users. Check the latest studies of Hydroxyurea.

On Jul, 12, 2026

19 people who take Depo-provera and Hydroxyurea together, and have interactions are studied.

Depo-provera and Hydroxyurea drug interactions.

What are the common drug interactions of Depo-Provera and Hydroxyurea, by gender? *:

female:

Diarrhoea
Pain
Lower extremity mass (mass in lower legs)
Abasia (inability to walk)
Abdominal pain
Anaemia (lack of blood)
Arrhythmia (irregular heartbeat)
Candidiasis (candidiasis or thrush is a fungal infection)
Cardiac arrest
Dehydration (dryness resulting from the removal of water)

male:

n/a

What are the common drug interactions of Depo-Provera and Hydroxyurea, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Desmoid tumour (fibrous tumour of muscle and connective tissue)
Diarrhoea
Joint swelling
Lower extremity mass (mass in lower legs)
Pain
Abasia (inability to walk)
Abdominal discomfort
Abdominal pain upper
Educational problem

20-29:

Abdominal pain
Anaemia (lack of blood)
Candidiasis (candidiasis or thrush is a fungal infection)
Haemorrhoidal haemorrhage (bleeding from the haemorrhoids)
Pain
Pharyngitis (inflammation of the pharynx, causing a sore throat)
Pyrexia (fever)

30-39:

Arrhythmia (irregular heartbeat)
Cardiac arrest
Sinus tachycardia (a heart rhythm with elevated rate of impulses originating from the sinoatrial node)
Strabismus (a disorder in which the two eyes do not line up in the same direction)
Vaccination site erythema (redness around vaccination site)
Vaccination site pruritus (severe itching of the skin at vaccination site)
Vaccination site rash
Vaccination site swelling
Chest pain
Dyspnoea (difficult or laboured respiration)

40-49:

n/a

50-59:

n/a

60+:

n/a

What are the existing conditions these people have? *

Haemochromatosis (body to absorb more iron than usual from food): 8 people, 42.11%
Iron Overload: 1 person, 5.26%

* Approximation only. Some reports may have incomplete information.

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