Depo-provera and Reglan drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Depo-provera (medroxyprogesterone acetate) and Reglan (metoclopramide hydrochloride). Common drug interactions include crying among females and weight increased among males.

The phase IV clinical study analyzes what interactions people have when they take Depo-provera and Reglan. It is created by eHealthMe based on reports of 55 people who take the same drugs from the FDA, and is updated regularly.

What is Depo-provera?

Depo-provera has active ingredients of medroxyprogesterone acetate. It is often used in birth control. eHealthMe is studying from 17,093 Depo-provera users. Check the latest studies of Depo-provera.

What is Reglan?

Reglan has active ingredients of metoclopramide hydrochloride. It is often used in gastroparesis. eHealthMe is studying from 29,455 Reglan users. Check the latest studies of Reglan.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 16, 2026

55 people who take Depo-provera and Reglan together, and have interactions are studied.

Depo-provera and Reglan drug interactions.

What are the common drug interactions of Depo-Provera and Reglan, by gender? *:

female:

Crying
Deafness neurosensory
Depression
Drug ineffective
Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation)
Electric shock
Gastric bypass
Malignant neoplasm progression (cancer tumour came back)
Migraine (headache)
Muscle spasms (muscle contraction)

male:

Weight increased
Increased appetite
Asthma
Erectile dysfunction
Hypertension (high blood pressure)
Penis disorder
Blood testosterone increased
Cardiomegaly (increased size of heart than normal)
Excessive masturbation
Hepatomegaly (abnormal enlargement of the liver)

What are the common drug interactions of Depo-Provera and Reglan, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Muscle spasms (muscle contraction)
Pain in extremity
Asthenia (weakness)
Cough
Dizziness
Fatigue (feeling of tiredness)
Headache (pain in head)
Malaise (a feeling of general discomfort or uneasiness)
Nasopharyngitis (inflammation of the nasopharynx)
Neuropathy peripheral (surface nerve damage)

20-29:

Dyspnoea (difficult or laboured respiration)
Headache (pain in head)
Pain
Actinomyces test positive
Acute psychosis (period of mentally unstable behaviour)
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Asthenia (weakness)
Bone disorder
Breath odour
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)

30-39:

Asthenia (weakness)
Bladder spasm
Blood alkaline phosphatase increased
Blood triglycerides increased
Blood urea increased
Death
Dehydration (dryness resulting from the removal of water)
Depressed mood
Depression
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)

40-49:

Aggression
Depression
Pain
Anion gap increased
Back disorder
Bipolar disorder (mood disorder)
Blood cholesterol increased
Blood testosterone increased
Cardiomegaly (increased size of heart than normal)
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)

50-59:

Weight increased
Increased appetite
Oedema (fluid collection in tissue)
Prostatic disorder
Asthma
Erectile dysfunction
Hypertension (high blood pressure)
Penis disorder
Sleep apnoea syndrome (a sleep-related disorder in which the effort to breathe is diminished or absent)
Abdominal distension

60+:

n/a

What are the existing conditions these people have? *

Asthma: 12 people, 21.82%
Pneumonia: 9 people, 16.36%
Diabetes: 8 people, 14.55%
Dyspnea (difficult or laboured breathing): 7 people, 12.73%
Renal Cell Carcinoma (a kidney cancer): 7 people, 12.73%
Psychotic Disorder: 7 people, 12.73%
Oedema (fluid collection in tissue): 7 people, 12.73%
Deep Venous Thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis): 7 people, 12.73%
Respiratory Tract Infection: 7 people, 12.73%
Fever: 7 people, 12.73%

* Approximation only. Some reports may have incomplete information.

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