Desflurane and Dexamethasone drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Desflurane (desflurane) and Dexamethasone (dexamethasone). Common drug interactions include anaphylactic shock among females and circulatory collapse among males.

The phase IV clinical study analyzes what interactions people have when they take Desflurane and Dexamethasone. It is created by eHealthMe based on reports of 53 people who take the same drugs from the FDA, and is updated regularly.

What is Desflurane?

Desflurane has active ingredients of desflurane. eHealthMe is studying from 1,270 Desflurane users. Check the latest studies of Desflurane.

What is Dexamethasone?

Dexamethasone has active ingredients of dexamethasone. It is often used in multiple myeloma. eHealthMe is studying from 161,927 Dexamethasone users. Check the latest studies of Dexamethasone.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 19, 2026

53 people who take Desflurane and Dexamethasone together, and have interactions are studied.

Desflurane and Dexamethasone drug interactions.

What are the common drug interactions of Desflurane and Dexamethasone, by gender? *:

female:

Anaphylactic shock (severe and rapid and sometimes fatal hypersensitivity reaction to a substance)
Blood pressure decreased
Circumoral oedema (swelling around mouth)
Sinus tachycardia (a heart rhythm with elevated rate of impulses originating from the sinoatrial node)
Tongue oedema (swelling of tongue)
Ventricular tachycardia (rapid heartbeat that originates in one of the lower chambers (the ventricles) of the heart)
Drug effect prolonged
Neuromuscular blockade
Anaphylactoid reaction (type of anaphylaxis that does not involve an allergic reaction but is due to direct mast cell degranulation)
Circulatory collapse

male:

Circulatory collapse
Asthenia (weakness)
Lipoma (a growth of fatty tissue that slowly develops just under your skin)
Oxygen saturation decreased
Tumour lysis syndrome (a group of metabolic complications that can occur after treatment of cancer, these complications are caused by the breakdown products of dying cancer cells)
Blood lactate dehydrogenase increased
Blood phosphorus increased
Blood pressure systolic increased
Bundle branch block (disruption in the normal flow of electrical pulses that drive the heart beat)
Cardiac failure acute

What are the common drug interactions of Desflurane and Dexamethasone, by age (0-1 to 60+)? *:

0-1:

Ventricular failure (heart failure)
Arrhythmia (irregular heartbeat)
Dyskinesia (abnormality or impairment of voluntary movement)
Hypertension (high blood pressure)
Mitral valve incompetence (inefficient heart valve)
Pulmonary arterial pressure increased
Tachycardia (a heart rate that exceeds the range of 100 beats/min)

2-9:

Respiratory distress (difficulty in breathing)
Asthenia (weakness)
Respiratory acidosis (respiratory failure or ventilatory failure, causes the ph of blood and other bodily fluids to decrease)
Hypoxia (low oxygen in tissues)
Respiration (transport of oxygen from the outside air to the cells within tissues)
Oxygen saturation decreased
Tumour lysis syndrome (a group of metabolic complications that can occur after treatment of cancer, these complications are caused by the breakdown products of dying cancer cells)
Blood lactate dehydrogenase increased
Blood phosphorus increased
Blood pressure systolic increased

10-19:

Carpal tunnel syndrome (nerve compression at wrist results numbness weakness, pain , swelling)
Lipoma (a growth of fatty tissue that slowly develops just under your skin)

20-29:

Brugada syndrome (life-threatening heart rhythm disorder)
Cardiac arrest
Fatigue (feeling of tiredness)
Hypotension (abnormally low blood pressure)
Sinus arrest (sinus pause)

30-39:

Hypotonia (low muscle tone)
Neuromuscular block prolonged
Psychotic disorder

40-49:

Ventricular tachycardia (rapid heartbeat that originates in one of the lower chambers (the ventricles) of the heart)
Electrocardiogram qt prolonged
Adverse drug reaction
Cervical spinal stenosis (narrowing of the spinal canal in the neck)
Clonus (series of involuntary, rhythmic, muscular contractions and relaxations)
Coronary artery disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)
Depressed level of consciousness
Dyskinesia (abnormality or impairment of voluntary movement)
Headache (pain in head)
Hemiparesis (weakness on one side of the body)

50-59:

Anaphylactoid reaction (type of anaphylaxis that does not involve an allergic reaction but is due to direct mast cell degranulation)
Circulatory collapse
Hyperthermia malignant (disease passed down through families that causes a fast rise in body temperature (fever) and severe muscle contractions)
Rhabdomyolysis (a condition in which damaged skeletal muscle tissue breaks down)
Anaphylactic reaction (serious allergic reaction)

60+:

Circulatory collapse
Anaphylactic shock (severe and rapid and sometimes fatal hypersensitivity reaction to a substance)
Arterial rupture
Asthenia (weakness)
Cogwheel rigidity (tension in a muscle which gives way in little jerks when the muscle is stretched)
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Depressed level of consciousness
Dysarthria (speech disorder)
Dysphagia (a condition in which swallowing is difficult or painful)
Extravasation (leakage of a fluid)

What are the existing conditions these people have? *

Anaesthesia: 21 people, 39.62%
High Blood Pressure: 9 people, 16.98%
Schizoaffective Disorder Bipolar Type (mental illness featuring schizophrenia and a mood disorder with mania): 7 people, 13.21%
General Anaesthesia: 6 people, 11.32%
Neuromuscular Blockade Reversal: 3 people, 5.66%
Neuromuscular Blockade: 3 people, 5.66%
Local Anaesthesia: 3 people, 5.66%

* Approximation only. Some reports may have incomplete information.

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