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Dexilant and Ocaliva drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Dexilant (dexlansoprazole) and Ocaliva (obeticholic acid). Common drug interactions include gastric antral vascular ectasia among females and abdominal pain upper among males.

The phase IV clinical study analyzes what interactions people have when they take Dexilant and Ocaliva. It is created by eHealthMe based on reports of 26 people who take the same drugs from the FDA, and is updated regularly.

What is Dexilant?

Dexilant has active ingredients of dexlansoprazole. It is often used in gastroesophageal reflux disease. eHealthMe is studying from 57,103 Dexilant users. Check the latest studies of Dexilant.

What is Ocaliva?

Ocaliva has active ingredients of obeticholic acid. eHealthMe is studying from 6,919 Ocaliva users. Check the latest studies of Ocaliva.

On Jul, 18, 2026

26 people who take Dexilant and Ocaliva together, and have interactions are studied.

Dexilant and Ocaliva drug interactions.

What are the common drug interactions of Dexilant and Ocaliva, by gender? *:

female:

  1. Gastric antral vascular ectasia (blood vessels in the lining of the stomach become fragile and become prone to rupture and bleeding)
  2. Gingival bleeding (bleeding gums)
  3. Haemoglobin decreased
  4. Splenomegaly (enlargement of spleen)
  5. Dizziness
  6. Myalgia (muscle pain)
  7. Surgery
  8. Abdominal discomfort
  9. Abdominal pain upper
  10. Gastritis (inflammation of stomach)

male:

  1. Abdominal pain upper
  2. Concomitant disease progression (progress in accompanying disease)
  3. Hospitalisation

What are the common drug interactions of Dexilant and Ocaliva, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

  1. Pruritus (severe itching of the skin)
  2. Asthenia (weakness)
  3. Emotional distress
  4. Epistaxis (bleed from the nose)
  5. Faeces discoloured
  6. Gastric antral vascular ectasia (blood vessels in the lining of the stomach become fragile and become prone to rupture and bleeding)
  7. Gingival bleeding (bleeding gums)
  8. Haemoglobin decreased
  9. Splenomegaly (enlargement of spleen)
  10. Myalgia (muscle pain)

60+:

  1. Pruritus (severe itching of the skin)
  2. Abdominal pain
  3. Asthenia (weakness)
  4. Chest discomfort
  5. Chest pain
  6. Chills (felling of cold)
  7. Dizziness
  8. Fatigue (feeling of tiredness)

What are the existing conditions these people have? *

  1. Biliary Cirrhosis Primary (primary biliary cirrhosis (pbc) is a long-term liver disease that damages the small bile ducts in the liver. the build-up of bile damages the liver): 7 people, 26.92%
  2. Gastritis (inflammation of stomach): 3 people, 11.54%

* Approximation only. Some reports may have incomplete information.

Do you take Dexilant and Ocaliva?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Dexilant and Ocaliva:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Dexilant:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Ocaliva:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Dexilant and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Ocaliva and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

How the study uses the data?

The study uses data from the FDA. It is based on dexlansoprazole and obeticholic acid (the active ingredients of Dexilant and Ocaliva, respectively), and Dexilant and Ocaliva (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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