Diflucan and Duphalac drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Diflucan (fluconazole) and Duphalac (lactulose). Common drug interactions include rash among females and cerebral infarction among males.

The phase IV clinical study analyzes what interactions people have when they take Diflucan and Duphalac. It is created by eHealthMe based on reports of 39 people who take the same drugs from the FDA, and is updated regularly.

What is Diflucan?

Diflucan has active ingredients of fluconazole. It is often used in vaginal yeast infection. eHealthMe is studying from 28,471 Diflucan users. Check the latest studies of Diflucan.

What is Duphalac?

Duphalac has active ingredients of lactulose. It is often used in constipation. eHealthMe is studying from 5,152 Duphalac users. Check the latest studies of Duphalac.

On Jul, 20, 2026

39 people who take Diflucan and Duphalac together, and have interactions are studied.

Diflucan and Duphalac drug interactions.

What are the common drug interactions of Diflucan and Duphalac, by gender? *:

female:

Rash
Hypokalaemia (low potassium)
Eosinophilia (eosinophil count in the peripheral blood exceeds)
Rash maculo-papular (red area on the skin that is covered with small confluent bumps)
Syncope (loss of consciousness with an inability to maintain postural tone)
Febrile neutropenia (fever with reduced white blood cells)
Anxiety
Arrhythmia (irregular heartbeat)
Blood pressure fluctuation
Drug eruption (adverse drug reaction of the skin)

male:

Cerebral infarction (less blood supply to brain resulting tissue damage)
Dizziness
Dermatitis acneiform (dermatoses including acne vulgaris, rosacea, folliculitis, and perioral dermatitis)
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Hepatic encephalopathy (spectrum of neuropsychiatric abnormalities in patients with liver failure)
Hepatic neoplasm malignant (liver cancer)
Malignant neoplasm progression (cancer tumour came back)
Performance status decreased
Peritonitis bacterial (inflammation of the peritoneum, the thin tissue that lines the inner wall of the abdomen and covers most of the abdominal organs by bacterial)
Cytomegalovirus infection

What are the common drug interactions of Diflucan and Duphalac, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Febrile neutropenia (fever with reduced white blood cells)

10-19:

n/a

20-29:

Cytomegalovirus infection
Fanconi syndrome acquired (self developed genetic disease of kidney damage due to defective transport system)
Febrile neutropenia (fever with reduced white blood cells)
Nephrogenic diabetes insipidus (a disorder in which a defect in the small tubes (tubules) in the kidneys causes a person to pass a large amount of urine)
Paralysis
Pyrexia (fever)
Renal tubular necrosis (death of kidney tubules)

30-39:

n/a

40-49:

Drug eruption (adverse drug reaction of the skin)
Pruritus (severe itching of the skin)

50-59:

Hypokalaemia (low potassium)
Syncope (loss of consciousness with an inability to maintain postural tone)
Arrhythmia (irregular heartbeat)
Blood pressure fluctuation

60+:

Rash
Cerebral infarction (less blood supply to brain resulting tissue damage)
Hepatic neoplasm malignant (liver cancer)
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Peritonitis bacterial (inflammation of the peritoneum, the thin tissue that lines the inner wall of the abdomen and covers most of the abdominal organs by bacterial)
Delirium (wild excitement)
Iliac artery occlusion (narrowing of an arterial segment between the aortic bifurcation and the groin)
Oedema (fluid collection in tissue)
Pyrexia (fever)
Dermatitis acneiform (dermatoses including acne vulgaris, rosacea, folliculitis, and perioral dermatitis)

What are the existing conditions these people have? *

High Blood Pressure: 10 people, 25.64%
Itching: 8 people, 20.51%
Locked-In Syndrome (a condition in which a patient is aware and awake but cannot move or communicate verbally due to complete paralysis): 6 people, 15.38%
Neuralgia (pain in one or more nerves): 6 people, 15.38%
Menopausal Symptoms: 6 people, 15.38%
Polycythaemia Vera (blood disorder in which the bone marrow makes too many red blood cells): 6 people, 15.38%
Urinary Incontinence (inability to control the flow of urine and involuntary urination): 6 people, 15.38%
Appetite - Decreased (decreased appetite occurs when you have a reduced desire to eat): 5 people, 12.82%
Lung Neoplasm Malignant (cancer tumour of lung): 4 people, 10.26%
Gastritis (inflammation of stomach): 4 people, 10.26%

* Approximation only. Some reports may have incomplete information.

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