Diflucan and Pramine drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Diflucan (fluconazole) and Pramine (imipramine hydrochloride). Common drug interactions include dyspnoea among females and angioedema among males.

The phase IV clinical study analyzes what interactions people have when they take Diflucan and Pramine. It is created by eHealthMe based on reports of 24 people who take the same drugs from the FDA, and is updated regularly.

What is Diflucan?

Diflucan has active ingredients of fluconazole. It is often used in vaginal yeast infection. eHealthMe is studying from 28,471 Diflucan users. Check the latest studies of Diflucan.

What is Pramine?

Pramine has active ingredients of imipramine hydrochloride. eHealthMe is studying from 7,461 Pramine users. Check the latest studies of Pramine.

On Aug, 03, 2026

24 people who take Diflucan and Pramine together, and have interactions are studied.

What are the common drug interactions of Diflucan and Pramine, by gender? *:

female:

Dyspnoea (difficult or laboured respiration)
Insomnia (sleeplessness)
Lymphadenopathy (disease or enlargement of lymph nodes)
Nausea (feeling of having an urge to vomit)
Oropharyngeal pain
Pain
Anxiety
Back pain
Cellulitis (infection under the skin)
Chest pain

male:

Angioedema (rapid swelling of the dermis)
Epistaxis (bleed from the nose)
Haemorrhage (bleeding)
Hallucination (an experience involving the perception of something not present)
Mouth haemorrhage (bleeding from mouth)
Pyrexia (fever)

What are the common drug interactions of Diflucan and Pramine, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Epistaxis (bleed from the nose)
Abdominal infection
Anaemia (lack of blood)
Anaphylactic reaction (serious allergic reaction)
Aphthous ulcer (mouth ulcer)
Appendicitis (inflammation of the appendix)
Arthralgia (joint pain)
Balance disorder
Cellulitis (infection under the skin)
Chest pain

40-49:

Coccidioidomycosis (serious disease of the lungs and other tissues, caused by the fungus coccidioides immitis)
Electrocardiogram qt corrected interval prolonged
Hepatic steatosis (fatty liver disease)
Immune reconstitution syndrome (immune recovery syndrome)
Lymphadenopathy (disease or enlargement of lymph nodes)
Mycobacterium avium complex infection
Pelvic mass
Splenomegaly (enlargement of spleen)
Anaemia (lack of blood)
Cardiopulmonary failure (cessation of normal circulation of the blood due to failure of the heart to contract)

50-59:

Blood sodium decreased
Blood thyroid stimulating hormone decreased
Blood thyroid stimulating hormone increased
Body temperature increased
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
C-reactive protein increased
Cardiolipin antibody positive
Cataract (clouding of the lens inside the eye)
Cellulitis (infection under the skin)
Chest discomfort

60+:

Asthenia (weakness)
Cough
Nausea (feeling of having an urge to vomit)
Nervousness
Pneumonia
Presyncope
Visual impairment
Chronic kidney disease
Renal failure (kidney dysfunction)
Tubulointerstitial nephritis (a form of nephritis affecting the interstitium of the kidneys surrounding the tubules)

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 3 people, 12.50%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 3 people, 12.50%
Urinary Tract Infection: 2 people, 8.33%
Pain: 2 people, 8.33%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 2 people, 8.33%
Hiv Infection: 2 people, 8.33%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 2 people, 8.33%

* Approximation only. Some reports may have incomplete information.

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