Diflucan and Ziac drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Diflucan (fluconazole) and Ziac (bisoprolol fumarate; hydrochlorothiazide). Common drug interactions include coronary artery disease among females and dyspnoea among males.

The phase IV clinical study analyzes what interactions people have when they take Diflucan and Ziac. It is created by eHealthMe based on reports of 52 people who take the same drugs from the FDA, and is updated regularly.

What is Diflucan?

Diflucan has active ingredients of fluconazole. It is often used in vaginal yeast infection. eHealthMe is studying from 28,471 Diflucan users. Check the latest studies of Diflucan.

What is Ziac?

Ziac has active ingredients of bisoprolol fumarate; hydrochlorothiazide. It is often used in high blood pressure. eHealthMe is studying from 4,451 Ziac users. Check the latest studies of Ziac.

On Jul, 13, 2026

52 people who take Diflucan and Ziac together, and have interactions are studied.

What are the common drug interactions of Diflucan and Ziac, by gender? *:

female:

Coronary artery disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)
Epiploic appendagitis (swelling or inflammation of the epiploic appendices, which are pouches in the lining of the abdominal)
Fluid overload (too much fluid in the blood)
Haemorrhoids (a swollen vein or group of veins in the region of the anus)
Heart rate increased
Pain in extremity
Platelet count decreased
Pain
Emotional distress
Arthritis (form of joint disorder that involves inflammation of one or more joints)

male:

Dyspnoea (difficult or laboured respiration)
Catheter related infection
Catheter site infection (infection at the site of insertion)
Diabetes mellitus inadequate control
Diarrhoea
Dry mouth
Gastritis (inflammation of stomach)
Hypoxia (low oxygen in tissues)
Insomnia (sleeplessness)
Iron deficiency

What are the common drug interactions of Diflucan and Ziac, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Malignant neoplasm of lacrimal duct (cancer tumour of tear duct)
Pancreatitis acute (sudden inflammation of pancreas)
Type 2 diabetes mellitus

30-39:

Cellulitis (infection under the skin)
Immune thrombocytopenic purpura (destruction of blood platelets due to the presence of antiplatelet auto antibodies)
Staphylococcal abscess (pus formation due to staphylococcal bacteria)
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Blood cholesterol increased
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Glaucoma (increased fluid pressure in the eye with vision loss)
Neuropathy peripheral (surface nerve damage)
Purpura senile (skin condition in which areas of the skin develop a purplish or reddish-brown appearance due to bleeding of small blood vessels underneath)

40-49:

Abdominal pain
Agitation (state of anxiety or nervous excitement)
Alopecia (absence of hair from areas of the body)
Anxiety
Diarrhoea
Dry mouth
Dyspnoea (difficult or laboured respiration)
Emotional distress
Insomnia (sleeplessness)
Nervousness

50-59:

Blood glucose increased
Coronary artery disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)
Dyspnoea (difficult or laboured respiration)
Fluid overload (too much fluid in the blood)
Heart rate increased
Platelet count decreased
Renal failure chronic (long lasting kidney dysfunction)
Renal tubular necrosis (death of kidney tubules)
Asthenia (weakness)
Blood thyroid stimulating hormone decreased

60+:

Abscess oral (abscess in the mouth)
Alveolar osteitis (complication of wound healing following extraction of a tooth)
Gingival abscess (pus in gums)
Gingival infection (gum infection)
Haemangioma (noncancerous, abnormally dense collections of dilated small blood vessels that may occur in the skin or internal organs)
Incision site infection (infection at incision site)
Inflammation
Lung neoplasm (tumour of lung)
Lymphadenopathy (disease or enlargement of lymph nodes)
Malignant neoplasm progression (cancer tumour came back)

What are the existing conditions these people have? *

Arthritis (form of joint disorder that involves inflammation of one or more joints): 13 people, 25.00%
Breast Cancer: 11 people, 21.15%
Pain: 8 people, 15.38%
Stress And Anxiety: 8 people, 15.38%
Immunodeficiency Common Variable: 6 people, 11.54%
Fungal Infection: 6 people, 11.54%
Pain In Extremity: 4 people, 7.69%
Muscle Spasms (muscle contraction): 4 people, 7.69%
Depression: 3 people, 5.77%
Bronchitis (inflammation of the mucous membrane in the bronchial tubes): 3 people, 5.77%

* Approximation only. Some reports may have incomplete information.

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