Digoxin and Cleocin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Digoxin (digoxin) and Cleocin (clindamycin phosphate). Common drug interactions include septic shock among females and dyspnoea among males.

The phase IV clinical study analyzes what interactions people have when they take Digoxin and Cleocin. It is created by eHealthMe based on reports of 74 people who take the same drugs from the FDA, and is updated regularly.

What is Digoxin?

Digoxin has active ingredients of digoxin. It is often used in atrial fibrillation/flutter. eHealthMe is studying from 93,740 Digoxin users. Check the latest studies of Digoxin.

What is Cleocin?

Cleocin has active ingredients of clindamycin phosphate. It is often used in infection. eHealthMe is studying from 3,940 Cleocin users. Check the latest studies of Cleocin.



On Jul, 10, 2026

74 people who take Digoxin and Cleocin together, and have interactions are studied.

Digoxin and Cleocin drug interactions.

What are the common drug interactions of Digoxin and Cleocin, by gender? *:

female:

  1. Septic shock (shock due to blood infection)
  2. Cellulitis (infection under the skin)
  3. Pleural effusion (water on the lungs)
  4. Cardiomegaly (increased size of heart than normal)
  5. Nausea (feeling of having an urge to vomit)
  6. Tricuspid valve incompetence (inefficient heart valve)
  7. Sepsis (a severe blood infection that can lead to organ failure and death)
  8. Cataract (clouding of the lens inside the eye)
  9. Hypotension (abnormally low blood pressure)
  10. Pain

male:

  1. Dyspnoea (difficult or laboured respiration)
  2. Pain
  3. Anxiety
  4. Cardiac failure congestive
  5. Dysaesthesia (abnormal sensation)
  6. Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
  7. Hypoaesthesia (reduced sense of touch or sensation)
  8. Neuralgia (pain in one or more nerves)
  9. Spinal osteoarthritis (joint cartilage loss in spine)
  10. Osteoarthritis (a joint disease caused by cartilage loss in a joint)

What are the common drug interactions of Digoxin and Cleocin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

  1. Cardiac disorder
  2. Cardiac failure congestive
  3. Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
  4. Hypoglycaemia (deficiency of glucose in the bloodstream)
  5. Injection site reaction
  6. Joint injury
  7. Migraine (headache)
  8. Thrombosis (formation of a blood clot inside a blood vessel)
  9. Type 1 diabetes mellitus
  10. Viral cardiomyopathy (weakness in the muscle of the heart due to viral infection)

30-39:

  1. Fluid retention (an abnormal accumulation of fluid in the blood)
  2. Nausea (feeling of having an urge to vomit)
  3. Abdominal distension
  4. Ascites (accumulation of fluid in the abdominal cavity)
  5. Diarrhoea
  6. Epistaxis (bleed from the nose)
  7. Flushing (the warm, red condition of human skin)
  8. Hernia (hernia happens when part of an internal organ or tissue bulges through a weak area of muscle)
  9. Hospitalisation
  10. Pain in jaw

40-49:

n/a

50-59:

  1. Pain in jaw
  2. Pleural effusion (water on the lungs)
  3. Pulmonary oedema (fluid accumulation in the lungs)
  4. Weight decreased
  5. Cataract (clouding of the lens inside the eye)
  6. Gait disturbance
  7. Pleural fibrosis (formation of fibrous tissue in lung)
  8. Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
  9. Anaemia (lack of blood)
  10. Asthenia (weakness)

60+:

  1. Cardiac failure congestive
  2. Coronary artery disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)
  3. Confusional state
  4. Back pain
  5. Bone disorder
  6. Injury
  7. Osteomyelitis (infection of bone)
  8. Renal cyst (kidney cyst)
  9. Weight decreased
  10. Arrhythmia (irregular heartbeat)

What are the existing conditions these people have? *

  1. Multiple Myeloma (cancer of the plasma cells): 25 people, 33.78%
  2. Toothaches (tooth pain): 14 people, 18.92%
  3. Muscle Spasms (muscle contraction): 11 people, 14.86%
  4. Hypercalcaemia Of Malignancy (elevated calcium (ca+) level in the blood with cancer): 10 people, 13.51%
  5. Pulmonary Hypertension (increase in blood pressure in the lung artery): 7 people, 9.46%
  6. Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 7 people, 9.46%
  7. Hypercalcaemia (elevated calcium (ca+) level in the blood): 5 people, 6.76%
  8. Depression: 4 people, 5.41%
  9. Cardiac Disorder: 4 people, 5.41%

* Approximation only. Some reports may have incomplete information.

Do you take Digoxin and Cleocin?

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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Digoxin and Cleocin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Digoxin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Cleocin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Digoxin and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Cleocin and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Related publications that referenced our studies


How the study uses the data?

The study uses data from the FDA. It is based on digoxin and clindamycin phosphate (the active ingredients of Digoxin and Cleocin, respectively), and Digoxin and Cleocin (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.



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