Diprivan and Naropin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Diprivan (propofol) and Naropin (ropivacaine hydrochloride monohydrate). Common drug interactions include bronchospasm among females and pulmonary oedema among males.

The phase IV clinical study analyzes what interactions people have when they take Diprivan and Naropin. It is created by eHealthMe based on reports of 64 people who take the same drugs from the FDA, and is updated regularly.

What is Diprivan?

Diprivan has active ingredients of propofol. eHealthMe is studying from 6,496 Diprivan users. Check the latest studies of Diprivan.

What is Naropin?

Naropin has active ingredients of ropivacaine hydrochloride monohydrate. eHealthMe is studying from 1,156 Naropin users. Check the latest studies of Naropin.

On Jul, 09, 2026

64 people who take Diprivan and Naropin together, and have interactions are studied.

What are the common drug interactions of Diprivan and Naropin, by gender? *:

female:

Bronchospasm (spasm of bronchial smooth muscle producing narrowing of the bronchi)
Cardioversion
Carotid pulse decreased
Circulatory collapse
Coagulopathy (blood's ability to clot is impaired)
Coma (state of unconsciousness lasting more than six hours)
Convulsions (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled of muscles contract and relax rapidly and repeatedly)
Cyanosis (lack of oxygen in body leads to blue appearance of skin ,mucous membrane nails)
Death
Delirium (wild excitement)

male:

Pulmonary oedema (fluid accumulation in the lungs)
Anaphylactic shock (severe and rapid and sometimes fatal hypersensitivity reaction to a substance)
Dyskinesia (abnormality or impairment of voluntary movement)
Hepatic enzyme increased
Hypoaesthesia (reduced sense of touch or sensation)
Jaundice (a yellowish pigmentation of the skin, the conjunctival membranes)
Monoparesis (one limb is very weak, but not completely paralyzed)
Movement disorder (neurological syndromes where they may be excess of movement or a paucity of movement that is not connected to weakness)
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Paralysis

What are the common drug interactions of Diprivan and Naropin, by age (0-1 to 60+)? *:

0-1:

Post procedural complication
Status epilepticus (a life-threatening condition in which the brain is in a state of persistent seizure)
Altered state of consciousness (altered state of mind)
Monoparesis (one limb is very weak, but not completely paralyzed)

2-9:

Anaphylactic shock (severe and rapid and sometimes fatal hypersensitivity reaction to a substance)
Clonic convulsion (long lasting seizure)
Depressed level of consciousness
Dysphagia (a condition in which swallowing is difficult or painful)
Overdose
Paralysis

10-19:

Joint injury
Musculoskeletal pain (pain affects the bones, muscles, ligaments, tendons, and nerves)

20-29:

Monoplegia (a paralysis of a single limb)
Cardiac arrest
Haemodynamic instability (disturbances in the blood movement in our body)
Haemoglobin decreased
Hypotension (abnormally low blood pressure)
Mydriasis (a dilation of the pupil)
Acute pulmonary oedema (sudden deposit of fluid in the lung))
Cardioversion
Carotid pulse decreased
Drug ineffective

30-39:

Pulmonary oedema (fluid accumulation in the lungs)
Hypotension (abnormally low blood pressure)
Illusion
Movement disorder (neurological syndromes where they may be excess of movement or a paucity of movement that is not connected to weakness)
Anaphylactoid shock (serious allergic reaction that is rapid in onset and may cause death)
Urticaria (rash of round, red welts on the skin that itch intensely)
Anaemia (lack of blood)
Blood pressure decreased
Cardiac arrest
Circulatory collapse

40-49:

Hyperhidrosis (abnormally increased sweating)
Hypotension (abnormally low blood pressure)
Hypovolaemia (a decreased volume of circulating blood in the body)
Intestinal functional disorder
Lesion of sciatic nerve (lesion of nerve of hip to leg)
Monoparesis (one limb is very weak, but not completely paralyzed)
Monoplegia (a paralysis of a single limb)
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Nerve injury
Nervous system disorder (a general class of medical conditions affecting the nervous system)

50-59:

Cardiac arrest
Acute respiratory distress syndrome
Blood glucose fluctuation
Hypotension (abnormally low blood pressure)
Renal failure (kidney dysfunction)
Respiratory failure (inadequate gas exchange by the respiratory system)
Arteriosclerosis coronary artery (thickening and hardening of arteries- coronary artery)
Hepatic congestion (liver congestion)
Pneumonia
Pneumonitis (inflammation of the walls of the alveoli in the lungs)

60+:

Bradycardia (abnormally slow heart action)
Atrioventricular block complete (heart block complete)
Application site inflammation
Application site pain
Arteriospasm coronary (spasm of the large- or medium-sized coronary arteries)
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Atrioventricular block (heart block)
Bronchospasm (spasm of bronchial smooth muscle producing narrowing of the bronchi)
Cardiac arrest
Coma (state of unconsciousness lasting more than six hours)

What are the existing conditions these people have? *

Epidural Anaesthesia: 13 people, 20.31%
General Anaesthesia: 11 people, 17.19%
Anaesthesia: 11 people, 17.19%
Local Anaesthesia: 4 people, 6.25%

* Approximation only. Some reports may have incomplete information.

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