Divalproex and Cannabis drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Divalproex (divalproex sodium) and Cannabis (marijuana). Common drug interactions include blood pressure decreased among females and hyperhidrosis among males.

The phase IV clinical study analyzes what interactions people have when they take Divalproex and Cannabis. It is created by eHealthMe based on reports of 25 people who take the same drugs from the FDA, and is updated regularly.

What is Divalproex?

Divalproex has active ingredients of divalproex sodium. It is often used in bipolar disorder. eHealthMe is studying from 14,063 Divalproex users. Check the latest studies of Divalproex.

What is Cannabis?

Cannabis has active ingredients of marijuana. It is often used in stress and anxiety. eHealthMe is studying from 13,371 Cannabis users. Check the latest studies of Cannabis.

On Jul, 19, 2026

25 people who take Divalproex and Cannabis together, and have interactions are studied.

Divalproex and Cannabis drug interactions.

What are the common drug interactions of Divalproex and Cannabis, by gender? *:

female:

Blood pressure decreased
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Heart rate decreased
Heart rate increased
Malaise (a feeling of general discomfort or uneasiness)
Nausea (feeling of having an urge to vomit)
Peripheral swelling
Pharyngitis streptococcal (inflammation of the pharynx caused by infection from. streptococcus)
Pyrexia (fever)

male:

Hyperhidrosis (abnormally increased sweating)
Renal failure (kidney dysfunction)
Sarcoidosis (an inflammatory disease that affects multiple organs in the body, but mostly the lungs and lymph glands)
Sepsis (a severe blood infection that can lead to organ failure and death)
Sinusitis (inflammation of sinus)
Type 1 diabetes mellitus
Ulcer haemorrhage (bleeding ulcer)
Hyperammonaemic encephalopathy (excess of ammonia in the blood, disorder or disease of the brain)
Infusion site bruising
Infusion site pruritus (severe itching at infusion site)

What are the common drug interactions of Divalproex and Cannabis, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Hyperammonaemic encephalopathy (excess of ammonia in the blood, disorder or disease of the brain)
Crohn's disease (a condition that causes inflammation of the gastrointestinal tract)
Agitation (state of anxiety or nervous excitement)
Confusional state
Dizziness
Eosinophilic pustular folliculitis (bacterial skin diseases)
Euphoric mood (excessively happy but may become angry or irritable)
Fatigue (feeling of tiredness)
Gait disturbance
Mood altered (changes in mood)

30-39:

Abdominal discomfort
Arthralgia (joint pain)
Back disorder
Blood pressure decreased
Drug ineffective
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Headache (pain in head)
Heart rate decreased
Heart rate increased

40-49:

Intestinal obstruction
Drug hypersensitivity
Hyponatraemia (abnormally low level of sodium in the blood; associated with dehydration)
Partial seizures (seizures which affect only a part of the brain at onset)

50-59:

Psychotic disorder
Agitation (state of anxiety or nervous excitement)
Dyspnoea (difficult or laboured respiration)
Paranoia (psychotic disorder characterized by delusions of persecution with or without grandeur)
Acute psychosis (period of mentally unstable behaviour)

60+:

Abdominal discomfort
Cough
Decreased appetite
Drug ineffective
Facial paralysis (loss of function of face muscle)
Migraine (headache)

What are the existing conditions these people have? *

Immunodeficiency Common Variable: 5 people, 20.00%
Migraine (headache): 4 people, 16.00%
Pain: 3 people, 12.00%
Insomnia (sleeplessness): 3 people, 12.00%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 3 people, 12.00%
Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 3 people, 12.00%
Schizoaffective Disorder (a mental disorder characterized by disordered thought): 2 people, 8.00%
Primary Immunodeficiency Syndrome: 2 people, 8.00%
Muscle Spasms (muscle contraction): 2 people, 8.00%
Hypopituitarism (diminished hormone secretion by the pituitary gland, causing dwarfism in children and premature aging in adults): 2 people, 8.00%

* Approximation only. Some reports may have incomplete information.

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