Divalproex and Cholestyramine drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Divalproex (divalproex sodium) and Cholestyramine (cholestyramine). Common drug interactions include blood glucose increased among females and chronic kidney disease among males.

The phase IV clinical study analyzes what interactions people have when they take Divalproex and Cholestyramine. It is created by eHealthMe based on reports of 33 people who take the same drugs from the FDA, and is updated regularly.

What is Divalproex?

Divalproex has active ingredients of divalproex sodium. It is often used in bipolar disorder. eHealthMe is studying from 14,063 Divalproex users. Check the latest studies of Divalproex.

What is Cholestyramine?

Cholestyramine has active ingredients of cholestyramine. It is often used in diarrhea. eHealthMe is studying from 9,893 Cholestyramine users. Check the latest studies of Cholestyramine.



On Jul, 15, 2026

33 people who take Divalproex and Cholestyramine together, and have interactions are studied.

Divalproex and Cholestyramine drug interactions.

What are the common drug interactions of Divalproex and Cholestyramine, by gender? *:

female:

  1. Blood glucose increased
  2. Chest pain
  3. Confusional state
  4. Depression
  5. Dry eye (lack of adequate tears)
  6. Gastrointestinal stoma complication (complication of an opening surgically made in digestive tract)
  7. Peripheral swelling
  8. Pneumonia
  9. Renal impairment (severely reduced kidney function)
  10. Sepsis (a severe blood infection that can lead to organ failure and death)

male:

  1. Chronic kidney disease
  2. Anhedonia (inability to experience pleasure from activities usually found enjoyable)
  3. Death
  4. Dysstasia (difficulty in standing)
  5. Seizure (abnormal excessive or synchronous neuronal activity in the brain)
  6. Urinary tract infection
  7. Abdominal discomfort
  8. Abnormal behaviour
  9. Asthenia (weakness)
  10. Ataxia (loss of full control of bodily movements)

What are the common drug interactions of Divalproex and Cholestyramine, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

  1. Chronic kidney disease
  2. Gait disturbance
  3. Anhedonia (inability to experience pleasure from activities usually found enjoyable)
  4. Anxiety
  5. Dysstasia (difficulty in standing)
  6. Emotional distress
  7. Pain
  8. Renal failure (kidney dysfunction)

50-59:

  1. Anxiety
  2. Anhedonia (inability to experience pleasure from activities usually found enjoyable)
  3. Chronic kidney disease
  4. Emotional distress
  5. Glomerulonephritis membranous (nephritis with inflammation of the capillary loops in the renal glomeruli)
  6. Pain
  7. Tooth loss
  8. Chest pain
  9. Confusional state
  10. Depression

60+:

  1. Death
  2. Gastrointestinal stoma complication (complication of an opening surgically made in digestive tract)
  3. Dementia alzheimer's type (loss of mental ability with alzheimer's symptom)
  4. Depressed mood
  5. Gait disturbance
  6. Glycosylated haemoglobin increased
  7. Hospitalisation
  8. Inappropriate affect
  9. Incoherent (talking in a confused and unclear way)
  10. Intervertebral disc degeneration (spinal disc degeneration)

What are the existing conditions these people have? *

  1. Hiv Infection: 5 people, 15.15%
  2. Multiple Myeloma (cancer of the plasma cells): 4 people, 12.12%
  3. Hyperkalemia (damage to or disease of the kidney): 3 people, 9.09%
  4. Gastrointestinal Stoma Complication (complication of an opening surgically made in digestive tract): 3 people, 9.09%
  5. Restless Leg Syndrome (a powerful urge to move your legs): 2 people, 6.06%

* Approximation only. Some reports may have incomplete information.

Do you take Divalproex and Cholestyramine?

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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Divalproex and Cholestyramine:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Divalproex:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Cholestyramine:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Divalproex and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Cholestyramine and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

How the study uses the data?

The study uses data from the FDA. It is based on divalproex sodium and cholestyramine (the active ingredients of Divalproex and Cholestyramine, respectively), and Divalproex and Cholestyramine (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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