Divalproex and Sulindac drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Divalproex (divalproex sodium) and Sulindac (sulindac). Common drug interactions include anxiety among females and anhedonia among males.

The phase IV clinical study analyzes what interactions people have when they take Divalproex and Sulindac. It is created by eHealthMe based on reports of 14 people who take the same drugs from the FDA, and is updated regularly.

What is Divalproex?

Divalproex has active ingredients of divalproex sodium. It is often used in bipolar disorder. eHealthMe is studying from 14,063 Divalproex users. Check the latest studies of Divalproex.

What is Sulindac?

Sulindac has active ingredients of sulindac. It is often used in rheumatoid arthritis. eHealthMe is studying from 3,824 Sulindac users. Check the latest studies of Sulindac.

On Jul, 15, 2026

14 people who take Divalproex and Sulindac together, and have interactions are studied.

Divalproex and Sulindac drug interactions.

What are the common drug interactions of Divalproex and Sulindac, by gender? *:

female:

Anxiety
Chronic kidney disease
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Osteoporosis (bones weak and more likely to break)
Renal failure (kidney dysfunction)
Alopecia (absence of hair from areas of the body)
Blood creatinine increased
Bone density decreased
Depression
Drug ineffective

male:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Ankle fracture
Anxiety
Chronic kidney disease
Emotional distress
Hyperphosphaturia (excess of phosphates in the urine)
Multiple fractures
Osteoporosis (bones weak and more likely to break)
Drug toxicity
Foot fracture

What are the common drug interactions of Divalproex and Sulindac, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Drug toxicity

30-39:

Alopecia (absence of hair from areas of the body)
Drug ineffective
Psoriatic arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop)

40-49:

Anxiety
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Chronic kidney disease
Osteoporosis (bones weak and more likely to break)
Blood creatinine increased
Bone density decreased
Depression
Liver disorder (liver diseases)
Post-traumatic stress disorder
Bone loss

50-59:

n/a

60+:

Chronic kidney disease
Renal failure (kidney dysfunction)
Clavicle fracture
Coma (state of unconsciousness lasting more than six hours)
Coordination abnormal (abnormal movement)
Diplopia (double vision)
Drug hypersensitivity
Dyspnoea (difficult or laboured respiration)
Emotional distress
Glaucoma (increased fluid pressure in the eye with vision loss)

What are the existing conditions these people have? *

Hiv Infection: 7 people, 50.00%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 4 people, 28.57%
Stress And Anxiety: 3 people, 21.43%
Depression: 3 people, 21.43%
Nausea (feeling of having an urge to vomit): 3 people, 21.43%
Muscle Spasms (muscle contraction): 3 people, 21.43%
Insomnia (sleeplessness): 3 people, 21.43%
Mental Disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability): 2 people, 14.29%
High Blood Pressure: 2 people, 14.29%
Hyperlipidaemia (presence of excess lipids in the blood): 2 people, 14.29%

* Approximation only. Some reports may have incomplete information.

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