Doxil and Levothyroxine sodium drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Doxil (doxorubicin hydrochloride) and Levothyroxine sodium (levothyroxine sodium). Common drug interactions include oedema among females and acute respiratory distress syndrome among males.

The phase IV clinical study analyzes what interactions people have when they take Doxil and Levothyroxine sodium. It is created by eHealthMe based on reports of 43 people who take the same drugs from the FDA, and is updated regularly.

What is Doxil?

Doxil has active ingredients of doxorubicin hydrochloride. It is often used in ovarian cancer. eHealthMe is studying from 10,479 Doxil users. Check the latest studies of Doxil.

What is Levothyroxine sodium?

Levothyroxine sodium has active ingredients of levothyroxine sodium. It is often used in hypothyroidism. eHealthMe is studying from 129,812 Levothyroxine sodium users. Check the latest studies of Levothyroxine sodium.



On Jul, 14, 2026

43 people who take Doxil and Levothyroxine sodium together, and have interactions are studied.

Doxil and Levothyroxine sodium drug interactions.

What are the common drug interactions of Doxil and Levothyroxine Sodium, by gender? *:

female:

  1. Oedema (fluid collection in tissue)
  2. Pain
  3. Cerebral ischaemia (insufficient blood flow to the brain to meet metabolic demand)
  4. Hypertension (high blood pressure)
  5. Petechiae (a small red or purple spot caused by bleeding into the skin)
  6. Somnolence (a state of near-sleep, a strong desire for sleep)
  7. Stomatitis (inflammation of mucous membrane of mouth)
  8. Anxiety
  9. Chest pain
  10. Emotional distress

male:

  1. Acute respiratory distress syndrome
  2. Renal failure acute (rapid kidney dysfunction)
  3. Chest pain
  4. Localised infection (infection at the single location)
  5. Musculoskeletal pain (pain affects the bones, muscles, ligaments, tendons, and nerves)
  6. Pericardial effusion (fluid around the heart)
  7. Pericarditis (inflammation of the pericardium)

What are the common drug interactions of Doxil and Levothyroxine Sodium, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

  1. Chest pain
  2. Localised infection (infection at the single location)
  3. Musculoskeletal pain (pain affects the bones, muscles, ligaments, tendons, and nerves)
  4. Pericardial effusion (fluid around the heart)
  5. Pericarditis (inflammation of the pericardium)

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

  1. Arthralgia (joint pain)
  2. Back pain
  3. Bone pain
  4. Chest pain
  5. Cyst (a closed sac)
  6. Deformity (disfigurement)
  7. Discomfort
  8. Epistaxis (bleed from the nose)
  9. Eye pain
  10. Fibromyalgia (a long-term condition which causes pain all over the body)

60+:

  1. Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets)
  2. Vomiting
  3. Communication disorder (speech and language disorder)
  4. Cough
  5. Dermatitis (inflammation of the skin resulting from direct irritation by an external agent or an allergic reaction to it)
  6. Leukopenia (less number of white blood cells in blood)
  7. Memory impairment
  8. Metastases to central nervous system (cancer spreads to central nervous system)
  9. Mobility decreased (ability to move is reduced)
  10. Neutropenic sepsis (whole body infection is caused by a condition in which the number of white blood cells (called neutrophils) in the blood is low. neutrophils help the body to fight infection)

What are the existing conditions these people have? *

  1. Multiple Myeloma (cancer of the plasma cells): 19 people, 44.19%
  2. High Blood Pressure: 10 people, 23.26%
  3. Insomnia (sleeplessness): 9 people, 20.93%
  4. Pain: 7 people, 16.28%
  5. Gastric Ulcer (stomach ulcer): 5 people, 11.63%
  6. Bone Pain: 5 people, 11.63%
  7. Nausea (feeling of having an urge to vomit): 4 people, 9.30%
  8. Nuclear Magnetic Resonance Imaging Brain: 3 people, 6.98%
  9. Nuclear Magnetic Resonance Imaging Abdominal: 3 people, 6.98%
  10. Neuropathy Peripheral (surface nerve damage): 3 people, 6.98%

* Approximation only. Some reports may have incomplete information.

Do you take Doxil and Levothyroxine sodium?

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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Doxil and Levothyroxine sodium:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Doxil:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Levothyroxine sodium:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Doxil and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Levothyroxine sodium and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

How the study uses the data?

The study uses data from the FDA. It is based on doxorubicin hydrochloride and levothyroxine sodium (the active ingredients of Doxil and Levothyroxine sodium, respectively), and Doxil and Levothyroxine sodium (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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