Dronabinol and Ritalin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Dronabinol (dronabinol) and Ritalin (methylphenidate hydrochloride). Common drug interactions include fatigue among females and pain among males.

The phase IV clinical study analyzes what interactions people have when they take Dronabinol and Ritalin. It is created by eHealthMe based on reports of 28 people who take the same drugs from the FDA, and is updated regularly.

What is Dronabinol?

Dronabinol has active ingredients of dronabinol. eHealthMe is studying from 5,453 Dronabinol users. Check the latest studies of Dronabinol.

What is Ritalin?

Ritalin has active ingredients of methylphenidate hydrochloride. It is often used in attention deficit hyperactivity disorder. eHealthMe is studying from 29,427 Ritalin users. Check the latest studies of Ritalin.



On Jul, 19, 2026

28 people who take Dronabinol and Ritalin together, and have interactions are studied.

Dronabinol and Ritalin drug interactions.

What are the common drug interactions of Dronabinol and Ritalin, by gender? *:

female:

  1. Fatigue (feeling of tiredness)
  2. Anaemia (lack of blood)
  3. Cardiac valve disease (heart valve disease)
  4. Diarrhoea
  5. Drug ineffective
  6. Flatulence (flatus expelled through the anus)
  7. Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
  8. Nausea (feeling of having an urge to vomit)
  9. Pericarditis (inflammation of the pericardium)
  10. Vomiting

male:

  1. Pain
  2. Abnormal loss of weight
  3. Quality of life decreased
  4. Renal impairment (severely reduced kidney function)
  5. Abdominal pain upper
  6. Agitation (state of anxiety or nervous excitement)
  7. Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
  8. Colitis ulcerative (inflammation of colon with ulcer)
  9. Constipation
  10. Decreased appetite

What are the common drug interactions of Dronabinol and Ritalin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

  1. Colitis ulcerative (inflammation of colon with ulcer)
  2. Impaired gastric emptying

20-29:

  1. Anhedonia (inability to experience pleasure from activities usually found enjoyable)
  2. Anxiety
  3. Emotional distress
  4. Loss of employment
  5. Osteopenia (a condition where bone mineral density is lower than normal)
  6. Osteoporosis (bones weak and more likely to break)
  7. Pain
  8. Quality of life decreased
  9. Renal impairment (severely reduced kidney function)
  10. Renal failure (kidney dysfunction)

30-39:

  1. Insomnia (sleeplessness)
  2. Lung transplant
  3. Abdominal pain upper
  4. Agitation (state of anxiety or nervous excitement)
  5. Gastrointestinal pain
  6. Headache (pain in head)
  7. Hospitalisation
  8. Hyperhidrosis (abnormally increased sweating)
  9. Irritability
  10. Palpitations (feelings or sensations that your heart is pounding or racing)

40-49:

  1. Anaemia (lack of blood)
  2. Diarrhoea
  3. Fatigue (feeling of tiredness)
  4. Flatulence (flatus expelled through the anus)
  5. Nausea (feeling of having an urge to vomit)
  6. Vomiting
  7. Alopecia (absence of hair from areas of the body)
  8. Asthenia (weakness)
  9. Dry eye (lack of adequate tears)
  10. Red blood cell count decreased

50-59:

  1. Hypotension (abnormally low blood pressure)
  2. Mitral valve incompetence (inefficient heart valve)
  3. Tricuspid valve incompetence (inefficient heart valve)
  4. Atelectasis (partial or complete collapse of the lung)
  5. Cardiac arrest
  6. Cardiac valve disease (heart valve disease)
  7. Hepatic cirrhosis (chronic liver disease characterized by replacement of liver tissue by fibrosis, scar tissue)
  8. Hypophagia (reduced food intake)
  9. Malaise (a feeling of general discomfort or uneasiness)
  10. Mental status changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation)

60+:

  1. Pericarditis (inflammation of the pericardium)
  2. Abnormal loss of weight
  3. Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
  4. Haemoglobin decreased
  5. Large intestinal obstruction
  6. Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets)
  7. Pneumonia
  8. Streptococcal bacteraemia (a bacterial infection of blood)

What are the existing conditions these people have? *

  1. Cataplexy (loss of muscle tone accompanied by full conscious awareness): 9 people, 32.14%
  2. Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 9 people, 32.14%
  3. Pain: 5 people, 17.86%
  4. Abdominal Pain Upper: 3 people, 10.71%
  5. Gastrointestinal Pain: 3 people, 10.71%
  6. Sleep Disorder: 3 people, 10.71%
  7. Ovarian Cancer (cancer of ovary): 3 people, 10.71%
  8. Nausea And Vomiting: 3 people, 10.71%
  9. Nausea (feeling of having an urge to vomit): 3 people, 10.71%
  10. Multiple Myeloma (cancer of the plasma cells): 3 people, 10.71%

* Approximation only. Some reports may have incomplete information.

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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Dronabinol and Ritalin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Dronabinol:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Ritalin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Dronabinol and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Ritalin and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Related publications that referenced our studies


How the study uses the data?

The study uses data from the FDA. It is based on dronabinol and methylphenidate hydrochloride (the active ingredients of Dronabinol and Ritalin, respectively), and Dronabinol and Ritalin (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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