Duopa and Naproxen drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Duopa (carbidopa; levodopa) and Naproxen (naproxen). Common drug interactions include rehabilitation therapy among females and pneumonia among males.

The phase IV clinical study analyzes what interactions people have when they take Duopa and Naproxen. It is created by eHealthMe based on reports of 36 people who take the same drugs from the FDA, and is updated regularly.

What is Duopa?

Duopa has active ingredients of carbidopa; levodopa. eHealthMe is studying from 8,208 Duopa users. Check the latest studies of Duopa.

What is Naproxen?

Naproxen has active ingredients of naproxen. It is often used in pain. eHealthMe is studying from 72,033 Naproxen users. Check the latest studies of Naproxen.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 19, 2026

36 people who take Duopa and Naproxen together, and have interactions are studied.

What are the common drug interactions of Duopa and Naproxen, by gender? *:

female:

Rehabilitation therapy
Decubitus ulcer (a chronic ulcer of the skin caused by prolonged pressure on it)
Hospitalisation
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Device dislocation
Hypertension (high blood pressure)
Meningitis (inflammation of the protective membranes covering the brain and spinal cord, known collectively as the meninges)
Mobility decreased (ability to move is reduced)
Nasal congestion (blockage of the nasal passages usually due to membranes lining the nose becoming swollen from inflamed blood vessels)
Osteomyelitis (infection of bone)

male:

Pneumonia
Fall
Surgery
Chronic lymphocytic leukaemia (cancer in which the bone marrow makes too many lymphocytes (a type of white blood cell))
Feeling cold
General physical health deterioration (weak health status)
Weight decreased
Device dislocation
Dissociation
Gait disturbance

What are the common drug interactions of Duopa and Naproxen, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

Hospitalisation
Feeling cold
Diarrhoea
Gastrointestinal infection (infection of stomach and intestine)
Mental disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability)
Pneumonia
Sepsis (a severe blood infection that can lead to organ failure and death)
Urinary tract infection
Carpal tunnel decompression

60+:

Rehabilitation therapy
Adverse drug reaction
Respiratory syncytial virus infection (viral disease of respiratory system)
Thrombosis (formation of a blood clot inside a blood vessel)
Upper respiratory tract infection
Akinesia (loss of control of voluntary muscle movements)
Anxiety
Asthenia (weakness)
Constipation
Coronary artery disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)

What are the existing conditions these people have? *

Parkinson's Disease: 18 people, 50.00%
Rapid Eye Movements Sleep Abnormal: 2 people, 5.56%
Muscle Spasms (muscle contraction): 2 people, 5.56%
High Blood Pressure: 2 people, 5.56%
Depression: 2 people, 5.56%

* Approximation only. Some reports may have incomplete information.

Do you take Duopa and Naproxen?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously