Duphalac and Acetylcysteine drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Duphalac (lactulose) and Acetylcysteine (acetylcysteine). Common drug interactions include renal impairment among females and hypokalaemia among males.

The phase IV clinical study analyzes what interactions people have when they take Duphalac and Acetylcysteine. It is created by eHealthMe based on reports of 61 people who take the same drugs from the FDA, and is updated regularly.

What is Duphalac?

Duphalac has active ingredients of lactulose. It is often used in constipation. eHealthMe is studying from 5,152 Duphalac users. Check the latest studies of Duphalac.

What is Acetylcysteine?

Acetylcysteine has active ingredients of acetylcysteine. It is often used in cough. eHealthMe is studying from 11,563 Acetylcysteine users. Check the latest studies of Acetylcysteine.

On Jul, 13, 2026

61 people who take Duphalac and Acetylcysteine together, and have interactions are studied.

Duphalac and Acetylcysteine drug interactions.

What are the common drug interactions of Duphalac and Acetylcysteine, by gender? *:

female:

Renal impairment (severely reduced kidney function)
Respiratory failure (inadequate gas exchange by the respiratory system)
Toxic epidermal necrolysis (a rare, life-threatening skin condition that is usually caused by a reaction to drugs causes wide spread skin destruction)
Vomiting
Hypokalaemia (low potassium)
Pneumonia
Blood bilirubin increased
Tumour lysis syndrome (a group of metabolic complications that can occur after treatment of cancer, these complications are caused by the breakdown products of dying cancer cells)
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Alanine aminotransferase increased

male:

Hypokalaemia (low potassium)
Liver carcinoma ruptured (ruptured liver cancer tumour)
Lower respiratory tract infection
Pneumonia
Vomiting
Abdominal pain upper
Alanine aminotransferase increased
Anaemia (lack of blood)
Arrhythmia (irregular heartbeat)
Back pain

What are the common drug interactions of Duphalac and Acetylcysteine, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Pneumonia
Vasoplegia syndrome (low systemic vascular resistance)

40-49:

Hypokalaemia (low potassium)
Liver carcinoma ruptured (ruptured liver cancer tumour)
Aspartate aminotransferase increased
Abdominal pain
Diarrhoea
Hepatic failure (liver failure)
Pneumonia aspiration (bronchopneumonia that develops due to the entrance of foreign materials into the bronchial tree)
Dyspnoea (difficult or laboured respiration)
Limb discomfort (discomfort in leg)
Nausea (feeling of having an urge to vomit)

50-59:

Death

60+:

Hypokalaemia (low potassium)
Device dislocation
Pneumonia
Vomiting
Aortic stenosis (obstruction to the outflow of blood from the left ventricle into the aorta)
Atrioventricular block (heart block)
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Diabetic end stage renal disease
Hypertensive nephropathy (hypertensive renal disease)
Joint swelling

What are the existing conditions these people have? *

High Blood Pressure: 22 people, 36.07%
Pain: 19 people, 31.15%
Headache (pain in head): 18 people, 29.51%
Abdominal Pain: 14 people, 22.95%
Weakness: 13 people, 21.31%
Diabetes: 13 people, 21.31%
Hepatic Neoplasm Malignant (liver cancer): 13 people, 21.31%
Hepatitis Alcoholic (inflammation of the liver due to alcohol): 11 people, 18.03%
Nausea (feeling of having an urge to vomit): 10 people, 16.39%
Pneumonia: 10 people, 16.39%

* Approximation only. Some reports may have incomplete information.

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