Duphalac and Akineton drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Duphalac (lactulose) and Akineton (biperiden hydrochloride). Common drug interactions include extrapyramidal disorder among females and confusional state among males.

The phase IV clinical study analyzes what interactions people have when they take Duphalac and Akineton. It is created by eHealthMe based on reports of 38 people who take the same drugs from the FDA, and is updated regularly.

What is Duphalac?

Duphalac has active ingredients of lactulose. It is often used in constipation. eHealthMe is studying from 5,152 Duphalac users. Check the latest studies of Duphalac.

What is Akineton?

Akineton has active ingredients of biperiden hydrochloride. It is often used in parkinson's disease. eHealthMe is studying from 6,140 Akineton users. Check the latest studies of Akineton.

On Jul, 27, 2026

38 people who take Duphalac and Akineton together, and have interactions are studied.

Duphalac and Akineton drug interactions.

What are the common drug interactions of Duphalac and Akineton, by gender? *:

female:

Extrapyramidal disorder (involuntary muscle spasms in the face and neck)
Balance disorder
Bradykinesia (decreased bodily movement. it is associated with basal ganglia diseases)
Cognitive disorder (mental health disorders affects learning, memory, perception, and problem solving)
Oxygen saturation decreased
Somnolence (a state of near-sleep, a strong desire for sleep)
Abscess (pus)
Depression
Infection
Leukopenia (less number of white blood cells in blood)

male:

Confusional state
Somnolence (a state of near-sleep, a strong desire for sleep)
Seizure (abnormal excessive or synchronous neuronal activity in the brain)
Stupor (lack of critical cognitive function and level of consciousness)
Hallucination, visual (seeing things that aren't there)
Memory impairment
Alcoholism (problems with alcohol)
Epilepsy (common and diverse set of chronic neurological disorders characterized by seizures)
Mania (a state of abnormally elevated or irritable mood)
Neutrophil count increased (excess than normal number of neutrophil a type of blood cell)

What are the common drug interactions of Duphalac and Akineton, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Coma (state of unconsciousness lasting more than six hours)
Hyperpyrexia (extremely high fever)
Lung infection
Rigors (an episode of shaking or exaggerated shivering)
Tremor (trembling or shaking movements in one or more parts of your body)
Fatigue (feeling of tiredness)
Hyperhidrosis (abnormally increased sweating)
Hyponatraemia (abnormally low level of sodium in the blood; associated with dehydration)
Inappropriate antidiuretic hormone secretion
Paralysis

30-39:

n/a

40-49:

Alcoholism (problems with alcohol)
Epilepsy (common and diverse set of chronic neurological disorders characterized by seizures)
Mania (a state of abnormally elevated or irritable mood)
Neutrophil count increased (excess than normal number of neutrophil a type of blood cell)
Red blood cell count decreased
White blood cell count increased
Respiratory failure (inadequate gas exchange by the respiratory system)
Somnolence (a state of near-sleep, a strong desire for sleep)
Vomiting
Depression

50-59:

Abdominal compartment syndrome (increased pressure in abdomen)
Ileus (a painful obstruction of the ileum or other part of the intestine)

60+:

Confusional state
Somnolence (a state of near-sleep, a strong desire for sleep)
Seizure (abnormal excessive or synchronous neuronal activity in the brain)
Stupor (lack of critical cognitive function and level of consciousness)
Hallucination, visual (seeing things that aren't there)
Memory impairment
Extrapyramidal disorder (involuntary muscle spasms in the face and neck)
Balance disorder
Bradykinesia (decreased bodily movement. it is associated with basal ganglia diseases)
Cognitive disorder (mental health disorders affects learning, memory, perception, and problem solving)

What are the existing conditions these people have? *

Schizophrenia (a mental disorder characterized by a breakdown of thought processes): 5 people, 13.16%
Hallucinations (sensations that appear real but are created by your mind): 5 people, 13.16%
Depression: 5 people, 13.16%
Dementia (madness): 5 people, 13.16%
Bipolar Disorder (mood disorder): 5 people, 13.16%
Mental Disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability): 4 people, 10.53%
Schizophrenia, Paranoid Type (delusions and auditory hallucinations but relatively normal intellectual functioning and expression of affect): 3 people, 7.89%
Back Pain: 2 people, 5.26%
Akinesia (loss of control of voluntary muscle movements): 2 people, 5.26%
Abnormal Behavior: 2 people, 5.26%

* Approximation only. Some reports may have incomplete information.

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